Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit

Abstract

AbstractDrosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How and when distinct types of LNs emerge, differentiate, and integrate into the olfactory circuit is unknown. Through systematic developmental analyses, we found that LNs are recruited to the adult olfactory circuit in three groups. Group 1 LNs are residual larval LNs. Group 2 are adult-specific LNs that emerge before cognate sensory and projection neurons establish synaptic specificity, and Group 3 LNs emerge after synaptic specificity is established. Group 1 larval LNs are selectively reintegrated into the adult circuit through pruning and re-extension of processes to distinct regions of the antennal lobe, while others die during metamorphosis. Precise temporal control of this pruning and cell death shapes the global organization of the adult antennal lobe. Our findings provide a road map to understand how LNs develop and contribute to constructing the olfactory circuit.

Autoren

Nan-Fu Liou
Shih-Han Lin
Ying-Jun Chen
Kuo-Ting Tsai
Chi-Jen Yang
Tzi-Yang Lin
Ting-Han Wu
Hsin-Ju Lin
Yuh-Tarng Chen
Daryl M Gohl
Marion Silies
Ya-Hui Chou

DOI

10.1038/s41467-018-04675-x

eISSN

2041-1723

Ausgabe der Veröffentlichung

1

Zeitschrift

Nature Communications

Sprache

en

Artikelnummer

2232

Online publication date

2018

Status

Published online

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1038/s41467-018-04675-x

Datum der Datenerfassung

2022

Titel

Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit

Ausgabe der Zeitschrift

9

Datenquelle: Crossref

Abstract

Drosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How and when distinct types of LNs emerge, differentiate, and integrate into the olfactory circuit is unknown. Through systematic developmental analyses, we found that LNs are recruited to the adult olfactory circuit in three groups. Group 1 LNs are residual larval LNs. Group 2 are adult-specific LNs that emerge before cognate sensory and projection neurons establish synaptic specificity, and Group 3 LNs emerge after synaptic specificity is established. Group 1 larval LNs are selectively reintegrated into the adult circuit through pruning and re-extension of processes to distinct regions of the antennal lobe, while others die during metamorphosis. Precise temporal control of this pruning and cell death shapes the global organization of the adult antennal lobe. Our findings provide a road map to understand how LNs develop and contribute to constructing the olfactory circuit.

Addresses

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.

Autoren

Nan-Fu Liou
Shih-Han Lin
Ying-Jun Chen
Kuo-Ting Tsai
Chi-Jen Yang
Tzi-Yang Lin
Ting-Han Wu
Hsin-Ju Lin
Yuh-Tarng Chen
Daryl M Gohl
Marion Silies
Ya-Hui Chou

DOI

10.1038/s41467-018-04675-x

eISSN

2041-1723

Externe Identifier

PubMed Identifier: 29884811
PubMed Central ID: PMC5993751

Funding acknowledgements

Ministry of Science and Technology, Taiwan: 101-2311-B-001-016-MY3
Academia Sinica: AS-102-CDA-L02
Ministry of Science and Technology, Taiwan: 104-2311-B-001-033-MY3
Ministry of Science and Technology, Taiwan: 101-2815-C-001-024-B
Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan): 104-2311-B-001-033-MY3
Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan): 101-2311-B-001-016-MY3
Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan): 101-2815-C-001-024-B

Open access

true

ISSN

2041-1723

Ausgabe der Veröffentlichung

1

Zeitschrift

Nature communications

Schlüsselwörter

Olfactory Receptor Neurons
Olfactory Pathways
Nerve Net
Interneurons
Animals
Animals, Genetically Modified
Drosophila melanogaster
Microscopy, Confocal
Synaptic Transmission
Morphogenesis
Larva
Models, Neurological
Time Factors
Arthropod Antennae

Sprache

eng

Medium

Electronic

Online publication date

2018

Open access status

Open Access

Paginierung

2232

Datum der Veröffentlichung

2018

Status

Published

Publisher licence

CC BY

Datum der Datenerfassung

2018

Titel

Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit.

Sub types

Research Support, Non-U.S. Gov't
research-article
Journal Article

Ausgabe der Zeitschrift

9

Files

https://www.nature.com/articles/s41467-018-04675-x.pdf https://europepmc.org/articles/PMC5993751?pdf=render

Datenquelle: Europe PubMed Central

Abstract

Drosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How and when distinct types of LNs emerge, differentiate, and integrate into the olfactory circuit is unknown. Through systematic developmental analyses, we found that LNs are recruited to the adult olfactory circuit in three groups. Group 1 LNs are residual larval LNs. Group 2 are adult-specific LNs that emerge before cognate sensory and projection neurons establish synaptic specificity, and Group 3 LNs emerge after synaptic specificity is established. Group 1 larval LNs are selectively reintegrated into the adult circuit through pruning and re-extension of processes to distinct regions of the antennal lobe, while others die during metamorphosis. Precise temporal control of this pruning and cell death shapes the global organization of the adult antennal lobe. Our findings provide a road map to understand how LNs develop and contribute to constructing the olfactory circuit.

Date of acceptance

2018

Autoren

Nan-Fu Liou
Shih-Han Lin
Ying-Jun Chen
Kuo-Ting Tsai
Chi-Jen Yang
Tzi-Yang Lin
Ting-Han Wu
Hsin-Ju Lin
Yuh-Tarng Chen
Daryl M Gohl
Marion Silies
Ya-Hui Chou

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/29884811

DOI

10.1038/s41467-018-04675-x

eISSN

2041-1723

Externe Identifier

PubMed Central ID: PMC5993751

Funding acknowledgements

Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan): 101-2815-C-001-024-B
Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan): 101-2311-B-001-016-MY3
Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan): 104-2311-B-001-033-MY3
Academia Sinica: AS-102-CDA-L02

Ausgabe der Veröffentlichung

1

Zeitschrift

Nat Commun

Schlüsselwörter

Animals
Animals, Genetically Modified
Arthropod Antennae
Drosophila melanogaster
Interneurons
Larva
Microscopy, Confocal
Models, Neurological
Morphogenesis
Nerve Net
Olfactory Pathways
Olfactory Receptor Neurons
Synaptic Transmission
Time Factors

Sprache

eng

Country

England

Paginierung

2232

PII

10.1038/s41467-018-04675-x

Datum der Veröffentlichung

2018

Status

Published online

Datum, an dem der Datensatz öffentlich gemacht wurde

2018

Titel

Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

9

Datenquelle: PubMed

Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit

Files

Werkzeuge