Layered reward signalling through octopamine and dopamine in Drosophila
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Christopher J Burke
- Wolf Huetteroth
- David Owald
- Emmanuel Perisse
- Michael J Krashes
- Gaurav Das
- Daryl Gohl
- Marion Silies
- Sarah Certel
- Scott Waddell
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000312488200057&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/nature11614
- eISSN
- 1476-4687
- Externe Identifier
- Clarivate Analytics Document Solution ID: 056KQ
- PubMed Identifier: 23103875
- ISSN
- 0028-0836
- Ausgabe der Veröffentlichung
- 7429
- Zeitschrift
- NATURE
- Paginierung
- 433 - +
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Layered reward signalling through octopamine and dopamine in <i>Drosophila</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 492
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Christopher J Burke
- Wolf Huetteroth
- David Owald
- Emmanuel Perisse
- Michael J Krashes
- Gaurav Das
- Daryl Gohl
- Marion Silies
- Sarah Certel
- Scott Waddell
- DOI
- 10.1038/nature11614
- eISSN
- 1476-4687
- ISSN
- 0028-0836
- Ausgabe der Veröffentlichung
- 7429
- Zeitschrift
- Nature
- Sprache
- en
- Online publication date
- 2012
- Paginierung
- 433 - 437
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/nature11614
- Datum der Datenerfassung
- 2023
- Titel
- Layered reward signalling through octopamine and dopamine in Drosophila
- Ausgabe der Zeitschrift
- 492
Datenquelle: Crossref
- Abstract
- Dopamine is synonymous with reward and motivation in mammals. However, only recently has dopamine been linked to motivated behaviour and rewarding reinforcement in fruitflies. Instead, octopamine has historically been considered to be the signal for reward in insects. Here we show, using temporal control of neural function in Drosophila, that only short-term appetitive memory is reinforced by octopamine. Moreover, octopamine-dependent memory formation requires signalling through dopamine neurons. Part of the octopamine signal requires the α-adrenergic-like OAMB receptor in an identified subset of mushroom-body-targeted dopamine neurons. Octopamine triggers an increase in intracellular calcium in these dopamine neurons, and their direct activation can substitute for sugar to form appetitive memory, even in flies lacking octopamine. Analysis of the β-adrenergic-like OCTβ2R receptor reveals that octopamine-dependent reinforcement also requires an interaction with dopamine neurons that control appetitive motivation. These data indicate that sweet taste engages a distributed octopamine signal that reinforces memory through discrete subsets of mushroom-body-targeted dopamine neurons. In addition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement systems in flies are more similar to mammals than previously thought.
- Addresses
- Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.
- Autoren
- Christopher J Burke
- Wolf Huetteroth
- David Owald
- Emmanuel Perisse
- Michael J Krashes
- Gaurav Das
- Daryl Gohl
- Marion Silies
- Sarah Certel
- Scott Waddell
- DOI
- 10.1038/nature11614
- eISSN
- 1476-4687
- Externe Identifier
- PubMed Identifier: 23103875
- PubMed Central ID: PMC3528794
- Funding acknowledgements
- Wellcome Trust: 090309/Z/09/Z
- NEI NIH HHS: F32EY020040
- NIMH NIH HHS: MH069883
- NEI NIH HHS: F32 EY020040
- Wellcome Trust: 090309
- NIMH NIH HHS: R01 MH081982
- NIMH NIH HHS: R01 MH069883
- Wellcome Trust:
- NIMH NIH HHS: MH081982
- Wellcome Trust: 090924
- Open access
- true
- ISSN
- 0028-0836
- Ausgabe der Veröffentlichung
- 7429
- Zeitschrift
- Nature
- Schlüsselwörter
- Mushroom Bodies
- Animals
- Drosophila melanogaster
- Octopamine
- Dopamine
- Drosophila Proteins
- Receptors, Neurotransmitter
- Appetitive Behavior
- Motivation
- Memory, Short-Term
- Reward
- Taste
- Signal Transduction
- Calcium Signaling
- Female
- Male
- Dopaminergic Neurons
- Conditioning, Psychological
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2012
- Open access status
- Open Access
- Paginierung
- 433 - 437
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2012
- Titel
- Layered reward signalling through octopamine and dopamine in Drosophila.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Research Support, N.I.H., Extramural
- Ausgabe der Zeitschrift
- 492
Files
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23103875/pdf/?tool=EBI https://europepmc.org/articles/PMC3528794?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Dopamine is synonymous with reward and motivation in mammals. However, only recently has dopamine been linked to motivated behaviour and rewarding reinforcement in fruitflies. Instead, octopamine has historically been considered to be the signal for reward in insects. Here we show, using temporal control of neural function in Drosophila, that only short-term appetitive memory is reinforced by octopamine. Moreover, octopamine-dependent memory formation requires signalling through dopamine neurons. Part of the octopamine signal requires the α-adrenergic-like OAMB receptor in an identified subset of mushroom-body-targeted dopamine neurons. Octopamine triggers an increase in intracellular calcium in these dopamine neurons, and their direct activation can substitute for sugar to form appetitive memory, even in flies lacking octopamine. Analysis of the β-adrenergic-like OCTβ2R receptor reveals that octopamine-dependent reinforcement also requires an interaction with dopamine neurons that control appetitive motivation. These data indicate that sweet taste engages a distributed octopamine signal that reinforces memory through discrete subsets of mushroom-body-targeted dopamine neurons. In addition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement systems in flies are more similar to mammals than previously thought.
- Date of acceptance
- 2012
- Autoren
- Christopher J Burke
- Wolf Huetteroth
- David Owald
- Emmanuel Perisse
- Michael J Krashes
- Gaurav Das
- Daryl Gohl
- Marion Silies
- Sarah Certel
- Scott Waddell
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23103875
- DOI
- 10.1038/nature11614
- eISSN
- 1476-4687
- Externe Identifier
- NIH Manuscript Submission ID: EMS50063
- PubMed Central ID: PMC3528794
- Funding acknowledgements
- NIMH NIH HHS: MH081982
- NEI NIH HHS: F32EY020040
- NIMH NIH HHS: R01 MH081982
- Wellcome Trust: 090309
- NIMH NIH HHS: MH069883
- Wellcome Trust:
- NIMH NIH HHS: R01 MH069883
- Wellcome Trust: 090924
- NEI NIH HHS: F32 EY020040
- Ausgabe der Veröffentlichung
- 7429
- Zeitschrift
- Nature
- Schlüsselwörter
- Animals
- Appetitive Behavior
- Calcium Signaling
- Conditioning, Psychological
- Dopamine
- Dopaminergic Neurons
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Male
- Memory, Short-Term
- Motivation
- Mushroom Bodies
- Octopamine
- Receptors, Neurotransmitter
- Reward
- Signal Transduction
- Taste
- Sprache
- eng
- Country
- England
- Paginierung
- 433 - 437
- PII
- nature11614
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2013
- Titel
- Layered reward signalling through octopamine and dopamine in Drosophila.
- Sub types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 492
Datenquelle: PubMed
- Beziehungen:
- Eigentum von