Aggressive Intrinsic Subtypes in Breast Cancer: A Predictor of Guideline Adherence in Older Patients With Breast Cancer?
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Florian Ebner
- Katharina Hancke
- Maria Blettner
- Lukas Schwentner
- Achim Wockel
- Rolf Kreienberg
- Wolfgang Janni
- Reyn van Ewijk
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000388588700002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.clbc.2015.03.003
- eISSN
- 1938-0666
- Externe Identifier
- Clarivate Analytics Document Solution ID: ED1EX
- PubMed Identifier: 25913904
- ISSN
- 1526-8209
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- CLINICAL BREAST CANCER
- Schlüsselwörter
- Breast cancer
- Guideline adherence
- Guideline-adherent treatment
- Guideline violations
- Older breast cancer patient
- Paginierung
- E189 - E195
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- Aggressive Intrinsic Subtypes in Breast Cancer: A Predictor of Guideline Adherence in Older Patients With Breast Cancer?
- Sub types
- Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Florian Ebner
- Katharina Hancke
- Maria Blettner
- Lukas Schwentner
- Achim Wöckel
- Rolf Kreienberg
- Wolfgang Janni
- Reyn van Ewijk
- DOI
- 10.1016/j.clbc.2015.03.003
- ISSN
- 1526-8209
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Clinical Breast Cancer
- Sprache
- en
- Paginierung
- e189 - e195
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.clbc.2015.03.003
- Datum der Datenerfassung
- 2022
- Titel
- Aggressive Intrinsic Subtypes in Breast Cancer: A Predictor of Guideline Adherence in Older Patients With Breast Cancer?
- Ausgabe der Zeitschrift
- 15
Datenquelle: Crossref
- Abstract
- <h4>Background</h4>Treatment side effects, comorbidities, and guideline-adherent treatment (GL+) influence the oncologic outcome of older breast cancer patients (oBCP) (age ≥ 70 years). The focus of this analysis was to investigate the associations among tumor characteristics, guideline adherence, and outcome and to compare these associations between younger breast cancer patients (yBCP) (age 50-69 years) and oBCP.<h4>Methods</h4>This is a retrospective multicenter cohort study with 17 participating certified breast cancer centers. The analysis of 10,897 patient records collected from 1992 to 2008 for GL+ and clinical outcome was performed. Tumor and patient characteristics and their associations with GL+ were compared between oBCP and yBCP.<h4>Results</h4>Nonguideline-adherent treatment (GL-) was associated with higher tumor stages and comorbidities. This effect was stronger in the oBCP group (P < .001). GL+ was significantly more common in yBCP than in oBCP (P < .001). The oBCP had significantly higher tumor stages, including tumor size (P < .001), nodal status (P < .001), and positive hormone receptors (P = .001). Tumor grading was lower (P = .001), and HER2neu overexpression was less frequent (P = .003) in oBCP. Overall survival and disease-free survival are significantly impaired if GL- occurred in patients with breast cancer independently of age.<h4>Conclusions</h4>GL- is associated with decreased disease-free survival and overall survival in both age groups. GL+ decreases advanced tumor characteristics in all age groups but significantly more in oBCP. If patients received GL+, we were unable to detect a statistical significant difference in the survival parameters.
- Addresses
- Universität Ulm, Klinik für Frauenheilkunde und Geburtshilfe, Ulm, Germany. Electronic address: florian.ebner@uniklinik-ulm.de.
- Autoren
- Florian Ebner
- Katharina Hancke
- Maria Blettner
- Lukas Schwentner
- Achim Wöckel
- Rolf Kreienberg
- Wolfgang Janni
- Reyn van Ewijk
- DOI
- 10.1016/j.clbc.2015.03.003
- eISSN
- 1938-0666
- Externe Identifier
- PubMed Identifier: 25913904
- Funding acknowledgements
- Bundesministerium für Bildung und Forschung: BMBF-Grant- 01ZP0505
- Open access
- false
- ISSN
- 1526-8209
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Clinical breast cancer
- Schlüsselwörter
- Humans
- Breast Neoplasms
- Retrospective Studies
- Cohort Studies
- Aged
- Middle Aged
- Guideline Adherence
- Female
- Practice Guidelines as Topic
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- e189 - e195
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- Aggressive Intrinsic Subtypes in Breast Cancer: A Predictor of Guideline Adherence in Older Patients With Breast Cancer?
- Sub types
- Research Support, Non-U.S. Gov't
- Multicenter Study
- Journal Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Europe PubMed Central
- Abstract
- BACKGROUND: Treatment side effects, comorbidities, and guideline-adherent treatment (GL+) influence the oncologic outcome of older breast cancer patients (oBCP) (age ≥ 70 years). The focus of this analysis was to investigate the associations among tumor characteristics, guideline adherence, and outcome and to compare these associations between younger breast cancer patients (yBCP) (age 50-69 years) and oBCP. METHODS: This is a retrospective multicenter cohort study with 17 participating certified breast cancer centers. The analysis of 10,897 patient records collected from 1992 to 2008 for GL+ and clinical outcome was performed. Tumor and patient characteristics and their associations with GL+ were compared between oBCP and yBCP. RESULTS: Nonguideline-adherent treatment (GL-) was associated with higher tumor stages and comorbidities. This effect was stronger in the oBCP group (P < .001). GL+ was significantly more common in yBCP than in oBCP (P < .001). The oBCP had significantly higher tumor stages, including tumor size (P < .001), nodal status (P < .001), and positive hormone receptors (P = .001). Tumor grading was lower (P = .001), and HER2neu overexpression was less frequent (P = .003) in oBCP. Overall survival and disease-free survival are significantly impaired if GL- occurred in patients with breast cancer independently of age. CONCLUSIONS: GL- is associated with decreased disease-free survival and overall survival in both age groups. GL+ decreases advanced tumor characteristics in all age groups but significantly more in oBCP. If patients received GL+, we were unable to detect a statistical significant difference in the survival parameters.
- Date of acceptance
- 2015
- Autoren
- Florian Ebner
- Katharina Hancke
- Maria Blettner
- Lukas Schwentner
- Achim Wöckel
- Rolf Kreienberg
- Wolfgang Janni
- Reyn van Ewijk
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25913904
- DOI
- 10.1016/j.clbc.2015.03.003
- eISSN
- 1938-0666
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Clin Breast Cancer
- Schlüsselwörter
- Breast cancer
- Guideline adherence
- Guideline violations
- Guideline-adherent treatment
- Older breast cancer patient
- Aged
- Breast Neoplasms
- Cohort Studies
- Female
- Guideline Adherence
- Humans
- Middle Aged
- Practice Guidelines as Topic
- Retrospective Studies
- Sprache
- eng
- Country
- United States
- Paginierung
- e189 - e195
- PII
- S1526-8209(15)00067-1
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- Aggressive Intrinsic Subtypes in Breast Cancer: A Predictor of Guideline Adherence in Older Patients With Breast Cancer?
- Sub types
- Journal Article
- Multicenter Study
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 15
Datenquelle: PubMed
- Beziehungen:
- Eigentum von