Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany A Retrospective, Hospital-based Surveillance

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Frank Kowalzik
  • Fred Zepp
  • Isabell Hoffmann
  • Harald Binder
  • Dagmar Lautz
  • Reyn van Ewijk
  • Markus Knuf
  • Tobias Tenenbaum
  • Martin Laass
  • Thorsten Reuter
  • Renate Schulze-Rath
  • Manuela Marron
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000376232600023&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1097/INF.0000000000000939
eISSN
1532-0987
Externe Identifier
  • Clarivate Analytics Document Solution ID: DM3FQ
  • PubMed Identifier: 26421806
ISSN
0891-3668
Ausgabe der Veröffentlichung
1
Zeitschrift
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Schlüsselwörter
  • rotavirus
  • gastroenteritis
  • burden
  • children
Paginierung
97 - 103
Datum der Veröffentlichung
2016
Status
Published
Titel
Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany <i>A Retrospective</i>, <i>Hospital</i>-<i>based Surveillance</i>
Sub types
  • Article
Ausgabe der Zeitschrift
35

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Frank Kowalzik
  • Fred Zepp
  • Isabell Hoffmann
  • Harald Binder
  • Dagmar Lautz
  • Reyn van Ewijk
  • Markus Knuf
  • Tobias Tenenbaum
  • Martin Laass
  • Thorsten Reuter
  • Renate Schulze-Rath
  • Manuela Marron
DOI
10.1097/inf.0000000000000939
ISSN
0891-3668
Ausgabe der Veröffentlichung
1
Zeitschrift
Pediatric Infectious Disease Journal
Sprache
en
Paginierung
97 - 103
Datum der Veröffentlichung
2016
Status
Published
Herausgeber
Ovid Technologies (Wolters Kluwer Health)
Herausgeber URL
http://dx.doi.org/10.1097/inf.0000000000000939
Datum der Datenerfassung
2021
Titel
Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany
Ausgabe der Zeitschrift
35

Datenquelle: Crossref

Abstract
<h4>Background</h4>Representative, population-based epidemiologic data for gastroenteritis caused by rotavirus (RV) are rare. RV vaccines were first licensed in Europe in 2006 and recommended in 5 western federal states in 2008 or thereafter. This study establishes a baseline for assessing the impact of vaccination and delineates the RV disease burden in Germany today.<h4>Methods</h4>Nationwide data obtained from hospitals for children 0 to 10 years of age and transferred to the Federal Statistical Office were analyzed retrospectively. Acute gastroenteritis cases because of RV were identified by the International Classification of Diseases code (ICD-10) combined with the referring diagnosis-related group code. Coding quality was validated by random sampling the patient records (n=1003). Crude and age-standardized rates per 100,000 person-years were calculated. The rate ratios of seasonal effects and recommended immunization adjusted for year, federal state and age were estimated using Poisson regression.<h4>Results</h4>Between 2005 and 2010, 5,843,730 children were hospitalized; 520,606 cases were hospitalized because of acute gastroenteritis. RV caused 152,636 of these cases or an age-standardized rate of 302 hospitalizations per 100,000 person-years. Rates were slightly higher in boys than girls, decreased with age, and differed by federal state, year and season. Rate ratios decreased in those western federal states that recommended immunization and were inversely associated with vaccine doses sold.<h4>Conclusions</h4>With an average of 25,440 children hospitalized yearly, RV infection has a great impact on the German healthcare system. Our findings indicate that RV immunization will lead to a decline in in-patient treatment and associated costs.
Addresses
  • From the *Pediatric Department and †Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; ‡Johannes Gutenberg University Mainz, Faculty of Economics, Mainz, Germany; §Klinikum der Landeshauptstadt Wiesbaden HSK, Dr Horst Schmidt Kliniken, Wiesbaden, Germany; ¶Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; ‖Pediatric Department, University Hospital Carl Gustav Carus, Dresden, Germany; **Sanofi Pasteur MSD GmbH, Leimen, Germany; and ††Institute for Community Medicine, University Medicine of the Ernst-Moritz-Arndt University, Greifswald, Germany.
Autoren
  • Frank Kowalzik
  • Fred Zepp
  • Isabell Hoffmann
  • Harald Binder
  • Dagmar Lautz
  • Reyn van Ewijk
  • Markus Knuf
  • Tobias Tenenbaum
  • Martin Laass
  • Thorsten Reuter
  • Renate Schulze-Rath
  • Manuela Marron
DOI
10.1097/inf.0000000000000939
eISSN
1532-0987
Externe Identifier
  • PubMed Identifier: 26421806
Open access
false
ISSN
0891-3668
Ausgabe der Veröffentlichung
1
Zeitschrift
The Pediatric infectious disease journal
Schlüsselwörter
  • Humans
  • Rotavirus
  • Rotavirus Infections
  • Gastroenteritis
  • Rotavirus Vaccines
  • Hospitalization
  • Odds Ratio
  • Retrospective Studies
  • Cost of Illness
  • Child
  • Child, Preschool
  • Infant
  • Infant, Newborn
  • Germany
  • Female
  • Male
  • Public Health Surveillance
  • Geography, Medical
Sprache
eng
Medium
Print
Paginierung
97 - 103
Datum der Veröffentlichung
2016
Status
Published
Datum der Datenerfassung
2015
Titel
Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany: A Retrospective, Hospital-based Surveillance.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
35

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Representative, population-based epidemiologic data for gastroenteritis caused by rotavirus (RV) are rare. RV vaccines were first licensed in Europe in 2006 and recommended in 5 western federal states in 2008 or thereafter. This study establishes a baseline for assessing the impact of vaccination and delineates the RV disease burden in Germany today. METHODS: Nationwide data obtained from hospitals for children 0 to 10 years of age and transferred to the Federal Statistical Office were analyzed retrospectively. Acute gastroenteritis cases because of RV were identified by the International Classification of Diseases code (ICD-10) combined with the referring diagnosis-related group code. Coding quality was validated by random sampling the patient records (n=1003). Crude and age-standardized rates per 100,000 person-years were calculated. The rate ratios of seasonal effects and recommended immunization adjusted for year, federal state and age were estimated using Poisson regression. RESULTS: Between 2005 and 2010, 5,843,730 children were hospitalized; 520,606 cases were hospitalized because of acute gastroenteritis. RV caused 152,636 of these cases or an age-standardized rate of 302 hospitalizations per 100,000 person-years. Rates were slightly higher in boys than girls, decreased with age, and differed by federal state, year and season. Rate ratios decreased in those western federal states that recommended immunization and were inversely associated with vaccine doses sold. CONCLUSIONS: With an average of 25,440 children hospitalized yearly, RV infection has a great impact on the German healthcare system. Our findings indicate that RV immunization will lead to a decline in in-patient treatment and associated costs.
Autoren
  • Frank Kowalzik
  • Fred Zepp
  • Isabell Hoffmann
  • Harald Binder
  • Dagmar Lautz
  • Reyn van Ewijk
  • Markus Knuf
  • Tobias Tenenbaum
  • Martin Laass
  • Thorsten Reuter
  • Renate Schulze-Rath
  • Manuela Marron
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/26421806
DOI
10.1097/INF.0000000000000939
eISSN
1532-0987
Ausgabe der Veröffentlichung
1
Zeitschrift
Pediatr Infect Dis J
Schlüsselwörter
  • Child
  • Child, Preschool
  • Cost of Illness
  • Female
  • Gastroenteritis
  • Geography, Medical
  • Germany
  • Hospitalization
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Odds Ratio
  • Public Health Surveillance
  • Retrospective Studies
  • Rotavirus
  • Rotavirus Infections
  • Rotavirus Vaccines
Sprache
eng
Country
United States
Paginierung
97 - 103
Datum der Veröffentlichung
2016
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2016
Titel
Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany: A Retrospective, Hospital-based Surveillance.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
35

Datenquelle: PubMed

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