Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Guillaume Grenier
- Anthony Scime
- Fabien Le Grand
- Atsushi Asakura
- Carolina Perez-Iratxeta
- Miguel A Andrade-Navarro
- Patricia A Labosky
- Michael A Rudnicki
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000251707200015&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1634/stemcells.2006-0795
- Externe Identifier
- Clarivate Analytics Document Solution ID: 242EL
- PubMed Identifier: 17823241
- ISSN
- 1066-5099
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- STEM CELLS
- Schlüsselwörter
- vasculogenesis
- endothelial precursors
- Sca1
- skeletal muscle
- Paginierung
- 3101 - 3110
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Titel
- Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis
- Sub types
- Article
- Ausgabe der Zeitschrift
- 25
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>A novel population of tissue-resident endothelial precursors (TEPs) was isolated from small blood vessels in dermal, adipose, and skeletal muscle of mouse based on their ability to be grown as spheres. Cellular and molecular analyses of these cells revealed that they were highly related regardless of the tissue of origin and distinct from embryonic neural stem cells. Notably, TEPs did not express hematopoietic markers, but they expressed numerous characteristics of angiogenic precursors and their differentiated progeny, such as CD34, Flk-1, Tie-1, CD31, and vascular endothelial cadherin (VE-cadherin). TEPs readily differentiated into endothelial cells in newly formed vascular networks following transplantation into regenerating skeletal muscle. Taken together, these experiments suggest that TEPs represent a novel class of endothelial precursors that are closely associated with small blood vessels in muscle, adipose, and dermal tissue. This finding is of particular interest since it could bring new insight in cancer angiogenesis and collateral blood vessels developed following ischemia.</jats:p><jats:p>Disclosure of potential conflicts of interest is found at the end of this article.</jats:p>
- Autoren
- Guillaume Grenier
- Anthony Scimè
- Fabien Le Grand
- Atsushi Asakura
- Carolina Perez-Iratxeta
- Miguel A Andrade-Navarro
- Patricia A Labosky
- Michael A Rudnicki
- DOI
- 10.1634/stemcells.2006-0795
- eISSN
- 1549-4918
- ISSN
- 1066-5099
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Stem Cells
- Sprache
- en
- Online publication date
- 2007
- Paginierung
- 3101 - 3110
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Herausgeber
- Oxford University Press (OUP)
- Herausgeber URL
- http://dx.doi.org/10.1634/stemcells.2006-0795
- Datum der Datenerfassung
- 2024
- Titel
- Resident Endothelial Precursors in Muscle, Adipose, and Dermis Contribute to Postnatal Vasculogenesis
- Ausgabe der Zeitschrift
- 25
Datenquelle: Crossref
- Abstract
- A novel population of tissue-resident endothelial precursors (TEPs) was isolated from small blood vessels in dermal, adipose, and skeletal muscle of mouse based on their ability to be grown as spheres. Cellular and molecular analyses of these cells revealed that they were highly related regardless of the tissue of origin and distinct from embryonic neural stem cells. Notably, TEPs did not express hematopoietic markers, but they expressed numerous characteristics of angiogenic precursors and their differentiated progeny, such as CD34, Flk-1, Tie-1, CD31, and vascular endothelial cadherin (VE-cadherin). TEPs readily differentiated into endothelial cells in newly formed vascular networks following transplantation into regenerating skeletal muscle. Taken together, these experiments suggest that TEPs represent a novel class of endothelial precursors that are closely associated with small blood vessels in muscle, adipose, and dermal tissue. This finding is of particular interest since it could bring new insight in cancer angiogenesis and collateral blood vessels developed following ischemia. Disclosure of potential conflicts of interest is found at the end of this article.
- Addresses
- Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
- Autoren
- Guillaume Grenier
- Anthony Scimè
- Fabien Le Grand
- Atsushi Asakura
- Carolina Perez-Iratxeta
- Miguel A Andrade-Navarro
- Patricia A Labosky
- Michael A Rudnicki
- DOI
- 10.1634/stemcells.2006-0795
- eISSN
- 1549-4918
- Externe Identifier
- PubMed Identifier: 17823241
- Open access
- false
- ISSN
- 1066-5099
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Stem cells (Dayton, Ohio)
- Schlüsselwörter
- Muscles
- Adipose Tissue
- Endothelium
- Cells, Cultured
- Spheroids, Cellular
- Stem Cells
- Dermis
- Animals
- Mice, Inbred BALB C
- Animals, Newborn
- Mice
- Cell Differentiation
- Morphogenesis
- Neovascularization, Physiologic
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2007
- Paginierung
- 3101 - 3110
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum der Datenerfassung
- 2007
- Titel
- Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis.
- Sub types
- Comparative Study
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 25
Datenquelle: Europe PubMed Central
- Abstract
- A novel population of tissue-resident endothelial precursors (TEPs) was isolated from small blood vessels in dermal, adipose, and skeletal muscle of mouse based on their ability to be grown as spheres. Cellular and molecular analyses of these cells revealed that they were highly related regardless of the tissue of origin and distinct from embryonic neural stem cells. Notably, TEPs did not express hematopoietic markers, but they expressed numerous characteristics of angiogenic precursors and their differentiated progeny, such as CD34, Flk-1, Tie-1, CD31, and vascular endothelial cadherin (VE-cadherin). TEPs readily differentiated into endothelial cells in newly formed vascular networks following transplantation into regenerating skeletal muscle. Taken together, these experiments suggest that TEPs represent a novel class of endothelial precursors that are closely associated with small blood vessels in muscle, adipose, and dermal tissue. This finding is of particular interest since it could bring new insight in cancer angiogenesis and collateral blood vessels developed following ischemia. Disclosure of potential conflicts of interest is found at the end of this article.
- Autoren
- Guillaume Grenier
- Anthony Scimè
- Fabien Le Grand
- Atsushi Asakura
- Carolina Perez-Iratxeta
- Miguel A Andrade-Navarro
- Patricia A Labosky
- Michael A Rudnicki
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/17823241
- DOI
- 10.1634/stemcells.2006-0795
- eISSN
- 1549-4918
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Stem Cells
- Schlüsselwörter
- Adipose Tissue
- Animals
- Animals, Newborn
- Cell Differentiation
- Cells, Cultured
- Dermis
- Endothelium
- Mice
- Mice, Inbred BALB C
- Morphogenesis
- Muscles
- Neovascularization, Physiologic
- Spheroids, Cellular
- Stem Cells
- Sprache
- eng
- Country
- England
- Paginierung
- 3101 - 3110
- PII
- 2006-0795
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2008
- Titel
- Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis.
- Sub types
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 25
Datenquelle: PubMed
- Beziehungen:
- Eigentum von