Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Autoren

Kathrin Reinmuth-Selzle
Christopher J Kampf
Kurt Lucas
Naama Lang-Yona
Janine Fröhlich-Nowoisky
Manabu Shiraiwa
Pascale SJ Lakey
Senchao Lai
Fobang Liu
Anna T Kunert
Kira Ziegler
Fangxia Shen
Rossella Sgarbanti
Bettina Weber
Iris Bellinghausen
Joachim Saloga
Michael G Weller
Albert Duschl
Detlef Schuppan
Ulrich Pöschl

DOI

10.1021/acs.est.6b04908

eISSN

1520-5851

ISSN

0013-936X

Ausgabe der Veröffentlichung

8

Zeitschrift

Environmental Science & Technology

Sprache

en

Online publication date

2017

Paginierung

4119 - 4141

Datum der Veröffentlichung

2017

Status

Published

Herausgeber

American Chemical Society (ACS)

Herausgeber URL

http://dx.doi.org/10.1021/acs.est.6b04908

Datum der Datenerfassung

2023

Titel

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Ausgabe der Zeitschrift

51

Datenquelle: Crossref

Abstract

Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immunogenicity of allergenic proteins, while climate change affects the atmospheric abundance and human exposure to bioaerosols and aeroallergens. To fully understand and effectively mitigate the adverse effects of air pollution and climate change on allergic diseases, several challenges remain to be resolved. Among these are the identification and quantification of immunochemical reaction pathways involving allergens and adjuvants under relevant environmental and physiological conditions.

Addresses

Multiphase Chemistry Department, Max Planck Institute for Chemistry , Mainz, 55128, Germany.

Autoren

Kathrin Reinmuth-Selzle
Christopher J Kampf
Kurt Lucas
Naama Lang-Yona
Janine Fröhlich-Nowoisky
Manabu Shiraiwa
Pascale SJ Lakey
Senchao Lai
Fobang Liu
Anna T Kunert
Kira Ziegler
Fangxia Shen
Rossella Sgarbanti
Bettina Weber
Iris Bellinghausen
Joachim Saloga
Michael G Weller
Albert Duschl
Detlef Schuppan
Ulrich Pöschl

DOI

10.1021/acs.est.6b04908

eISSN

1520-5851

Externe Identifier

PubMed Identifier: 28326768
PubMed Central ID: PMC5453620

Funding acknowledgements

China Scholarship Council:
Deutsche Forschungsgemeinschaft: DFG FR3641/1-2
Max-Planck-Gesellschaft:
Weizmann Institute of Science:
Deutsche Forschungsgemeinschaft: FOR 1525 INUIT
Deutsche Forschungsgemeinschaft: KA 4008-1/1
Austrian Science Fund FWF: W-1213
Universit?t Salzburg:

Open access

true

ISSN

0013-936X

Ausgabe der Veröffentlichung

8

Zeitschrift

Environmental science & technology

Schlüsselwörter

Humans
Hypersensitivity
Allergens
Air Pollutants
Air Pollution
Climate Change

Sprache

eng

Medium

Print-Electronic

Online publication date

2017

Open access status

Open Access

Paginierung

4119 - 4141

Datum der Veröffentlichung

2017

Status

Published

Datum der Datenerfassung

2017

Titel

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.

Sub types

Research Support, Non-U.S. Gov't
review-article
Journal Article

Ausgabe der Zeitschrift

51

Files

https://europepmc.org/articles/PMC5453620?pdf=render

Datenquelle: Europe PubMed Central

Abstract

Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immunogenicity of allergenic proteins, while climate change affects the atmospheric abundance and human exposure to bioaerosols and aeroallergens. To fully understand and effectively mitigate the adverse effects of air pollution and climate change on allergic diseases, several challenges remain to be resolved. Among these are the identification and quantification of immunochemical reaction pathways involving allergens and adjuvants under relevant environmental and physiological conditions.

Autoren

Kathrin Reinmuth-Selzle
Christopher J Kampf
Kurt Lucas
Naama Lang-Yona
Janine Fröhlich-Nowoisky
Manabu Shiraiwa
Pascale SJ Lakey
Senchao Lai
Fobang Liu
Anna T Kunert
Kira Ziegler
Fangxia Shen
Rossella Sgarbanti
Bettina Weber
Iris Bellinghausen
Joachim Saloga
Michael G Weller
Albert Duschl
Detlef Schuppan
Ulrich Pöschl

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/28326768

DOI

10.1021/acs.est.6b04908

eISSN

1520-5851

Externe Identifier

PubMed Central ID: PMC5453620

Ausgabe der Veröffentlichung

8

Zeitschrift

Environ Sci Technol

Schlüsselwörter

Air Pollutants
Air Pollution
Allergens
Climate Change
Humans
Hypersensitivity

Sprache

eng

Country

United States

Paginierung

4119 - 4141

Datum der Veröffentlichung

2017

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2017

Titel

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

51

Datenquelle: PubMed

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Files

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