Growth-Promoting Treatment Screening for Corticospinal Neurons in Mouse and Man
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Neurons of the central nervous system (CNS) that project long axons into the spinal cord have a poor axon regenerative capacity compared to neurons of the peripheral nervous system. The corticospinal tract (CST) is particularly notorious for its poor regeneration. Because of this, traumatic spinal cord injury (SCI) is a devastating condition that remains as yet uncured. Based on our recent observations that direct neuronal interleukin-4 (IL-4) signaling leads to repair of axonal swellings and beneficial effects in neuroinflammation, we hypothesized that IL-4 acts directly on the CST. Here, we developed a tissue culture model for CST regeneration and found that IL-4 promoted new growth cone formation after axon transection. Most importantly, IL-4 directly increased the regenerative capacity of both murine and human CST axons, which corroborates its regenerative effects in CNS damage. Overall, these findings serve as proof-of-concept that our CST regeneration model is suitable for fast screening of new treatments for SCI.</jats:p>
- Autoren
- Nicholas Hanuscheck
- Andrea Schnatz
- Carine Thalman
- Steffen Lerch
- Yvonne Gärtner
- Micaela Domingues
- Lynn Bitar
- Robert Nitsch
- Frauke Zipp
- Christina F Vogelaar
- DOI
- 10.1007/s10571-020-00820-7
- eISSN
- 1573-6830
- ISSN
- 0272-4340
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Cellular and Molecular Neurobiology
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 1327 - 1338
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s10571-020-00820-7
- Datum der Datenerfassung
- 2021
- Titel
- Growth-Promoting Treatment Screening for Corticospinal Neurons in Mouse and Man
- Ausgabe der Zeitschrift
- 40
Datenquelle: Crossref
- Andere Metadatenquellen:
-
- Author's licence
- CC-BY
- Autoren
- Nicholas Hanuscheck
- Andrea Schnatz
- Carine Thalman
- Steffen Lerch
- Yvonne Gärtner
- Micaela Domingues
- Lynn Bitar
- Robert Nitsch
- Frauke Zipp
- Christina F Vogelaar
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1007/s10571-020-00820-7
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1573-6830
- Zeitschrift
- Cellular and molecular neurobiology
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 1327 - 1338
- Datum der Veröffentlichung
- 2020
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/5793
- Herausgeber
- Springer Science + Business Media B.V
- Herausgeber URL
- https://doi.org/10.1007/s10571-020-00820-7
- Datum der Datenerfassung
- 2021
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Zugang
- Public
- Titel
- Growth-promoting treatment screening for corticospinal neurons in mouse and man
- Ausgabe der Zeitschrift
- 40
Files
hanuscheck_nicholas-growth-promoti-20210420205909752.pdf
Datenquelle: OPENSCIENCE.UB