Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study

Publikationstyp:

Zeitschriftenaufsatz

Metadaten:

Autoren

Katharina Bahr
Michael Bopp
Waeel Kewader
Henri Dootz
Julia Doege
Tilman Huppertz
Perikles Simon
Verena Prokosch-Willing
Christoph Matthias
Haralampos Gouveris

Autoren-URL

https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000578557700004&DestLinkType=FullRecord&DestApp=WOS_CPL

DOI

10.1186/s12931-020-01533-7

eISSN

1465-993X

Externe Identifier

Clarivate Analytics Document Solution ID: OB6CU
PubMed Identifier: 33032589

Ausgabe der Veröffentlichung

Zeitschrift

RESPIRATORY RESEARCH

Schlüsselwörter

Obstructive sleep apnea
Sleep-disordered breathing
Glaucoma
Primary open angle glaucoma

Artikelnummer

ARTN 258

Datum der Veröffentlichung

2020

Status

Published

Titel

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study

Sub types

Article

Ausgabe der Zeitschrift

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:

Abstract

Abstract Background Both glaucoma and obstructive sleep apnea (OSA) are widespread diseases. OSA may presumably partly cause or worsen glaucoma, although the etiopathogenesis is unclear. Here we analyze for the first time the possible association between different glaucoma phenotypes and OSA. Methods 110 patients (47 females, 63 males; median age 64.3 years, median BMI 26.62 kg/m2) with suspected glaucoma and without any prior diagnosis of OSA were prospectively studied by one-night home sleep apnea testing (HSAT), 101 of the patients were analyzed. HSAT parameters, like apnea hypopnea index (AHI) and oxygen desaturation index as well as opthalmological parameters like intraocular pressure (IOP) and mean defect depth (MD) were collected. Moreover, HSAT results were compared across four phenotypic groups: primary open angle glaucoma (POAG), low-tension-glaucoma (LTG), ocular hypertension (OH), and controls. Results There was no strong correlation between IOP or MD and AHI. BMI, age and gender did not differ between groups. Significant differences between POAG and LTG were found for all HSAT parameters. The AHI showed the most prominent group difference (Wilcoxon-Kruskal-Wallis rank sum test was highly significant with chi2 = 22, df = 3 p < 0.0001) with severely lower event rates in the LTG (9.45/h) compared to POAG (22.7/h) and controls (21.9/h; p < 0.0001 and 0.02, respectively). Highly significant differences were found between the four groups regarding AHI (Chi2 = 22, df = 3, p < 0.0001) with significantly lower events per hour in the LTG compared to POAG (Hodges-Lehmann = − 13.8, 95% CI (− 18.6 – − 8.8; p < 0.0001) and to controls (Hodges-Lehmann = 12.1, 95% CI -19.9 – − 2.4; p < 0.02). Severe and moderate OSA was more prevalent in POAG (69.8%) and OH (33.3%) than in LTG (9%). The effect of the glaucoma phenotype on the AHI was more prominent in females (p = 0.0006) than in males (p = 0.011). Conclusion Although physical endpoints, such as MD and IOP, do not correlate with AHI, there was a strong correlation between the POAG and OH clinical glaucoma phenotypes and the AHI. Further studies should investigate the necessity to test routine screening for OSA by HSAT in patients with diagnosed POAG and OH. Besides, some characteristics of LTG differed widely from other glaucoma types and controls. LTG patients had a significantly lower rate of OSA compared to other glaucoma types and even controls. This might be due to a different pathogenesis of LTG. Trial registration Retrospectively registered at DRKS (nr. S00021201) on April 9th 2020.

Autoren

Katharina Bahr
Michael Bopp
Waeel Kewader
Henri Dootz
Julia Döge
Tilman Huppertz
Perikles Simon
Verena Prokosch-Willing
Christoph Matthias
Haralampos Gouveris

DOI

10.1186/s12931-020-01533-7

eISSN

1465-993X

Ausgabe der Veröffentlichung

Zeitschrift

Respiratory Research

Sprache

Artikelnummer

258

Online publication date

2020

Datum der Veröffentlichung

2020

Status

Published

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1186/s12931-020-01533-7

Datum der Datenerfassung

2021

Titel

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study

Ausgabe der Zeitschrift

Datenquelle: Crossref

Abstract

<h4>Background</h4>Both glaucoma and obstructive sleep apnea (OSA) are widespread diseases. OSA may presumably partly cause or worsen glaucoma, although the etiopathogenesis is unclear. Here we analyze for the first time the possible association between different glaucoma phenotypes and OSA.<h4>Methods</h4>110 patients (47 females, 63 males; median age 64.3 years, median BMI 26.62 kg/m<sup>2</sup>) with suspected glaucoma and without any prior diagnosis of OSA were prospectively studied by one-night home sleep apnea testing (HSAT), 101 of the patients were analyzed. HSAT parameters, like apnea hypopnea index (AHI) and oxygen desaturation index as well as opthalmological parameters like intraocular pressure (IOP) and mean defect depth (MD) were collected. Moreover, HSAT results were compared across four phenotypic groups: primary open angle glaucoma (POAG), low-tension-glaucoma (LTG), ocular hypertension (OH), and controls.<h4>Results</h4>There was no strong correlation between IOP or MD and AHI. BMI, age and gender did not differ between groups. Significant differences between POAG and LTG were found for all HSAT parameters. The AHI showed the most prominent group difference (Wilcoxon-Kruskal-Wallis rank sum test was highly significant with chi<sup>2</sup> = 22, df = 3 p < 0.0001) with severely lower event rates in the LTG (9.45/h) compared to POAG (22.7/h) and controls (21.9/h; p < 0.0001 and 0.02, respectively). Highly significant differences were found between the four groups regarding AHI (Chi<sup>2</sup> = 22, df = 3, p < 0.0001) with significantly lower events per hour in the LTG compared to POAG (Hodges-Lehmann = - 13.8, 95% CI (- 18.6 - - 8.8; p < 0.0001) and to controls (Hodges-Lehmann = 12.1, 95% CI -19.9 - - 2.4; p < 0.02). Severe and moderate OSA was more prevalent in POAG (69.8%) and OH (33.3%) than in LTG (9%). The effect of the glaucoma phenotype on the AHI was more prominent in females (p = 0.0006) than in males (p = 0.011).<h4>Conclusion</h4>Although physical endpoints, such as MD and IOP, do not correlate with AHI, there was a strong correlation between the POAG and OH clinical glaucoma phenotypes and the AHI. Further studies should investigate the necessity to test routine screening for OSA by HSAT in patients with diagnosed POAG and OH. Besides, some characteristics of LTG differed widely from other glaucoma types and controls. LTG patients had a significantly lower rate of OSA compared to other glaucoma types and even controls. This might be due to a different pathogenesis of LTG.<h4>Trial registration</h4>Retrospectively registered at DRKS ( nr. S00021201 ) on April 9th 2020.

Addresses

Sleep Medicine Center, Department of Otorhinolaryngology, Head and Neck Surgery, Medical Center of the University of Mainz, 55131, Mainz, Germany. katharina.bahr@unimedizin-mainz.de.

Autoren

Katharina Bahr
Michael Bopp
Waeel Kewader
Henri Dootz
Julia Döge
Tilman Huppertz
Perikles Simon
Verena Prokosch-Willing
Christoph Matthias
Haralampos Gouveris

DOI

10.1186/s12931-020-01533-7

eISSN

1465-993X

Externe Identifier

PubMed Identifier: 33032589
PubMed Central ID: PMC7545869

Open access

true

ISSN

1465-9921

Ausgabe der Veröffentlichung

Zeitschrift

Respiratory research

Schlüsselwörter

Humans
Sleep Apnea, Obstructive
Ocular Hypertension
Glaucoma, Open-Angle
Risk Factors
Retrospective Studies
Pilot Projects
Aged
Middle Aged
Female
Male

Sprache

eng

Medium

Electronic

Online publication date

2020

Open access status

Open Access

Paginierung

258

Datum der Veröffentlichung

2020

Status

Published

Publisher licence

CC BY

Datum der Datenerfassung

2020

Titel

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study.

Sub types

Clinical Trial
research-article
Journal Article

Ausgabe der Zeitschrift

Files

https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-020-01533-7 https://europepmc.org/articles/PMC7545869?pdf=render

Datenquelle: Europe PubMed Central

Abstract

BACKGROUND: Both glaucoma and obstructive sleep apnea (OSA) are widespread diseases. OSA may presumably partly cause or worsen glaucoma, although the etiopathogenesis is unclear. Here we analyze for the first time the possible association between different glaucoma phenotypes and OSA. METHODS: 110 patients (47 females, 63 males; median age 64.3 years, median BMI 26.62 kg/m2) with suspected glaucoma and without any prior diagnosis of OSA were prospectively studied by one-night home sleep apnea testing (HSAT), 101 of the patients were analyzed. HSAT parameters, like apnea hypopnea index (AHI) and oxygen desaturation index as well as opthalmological parameters like intraocular pressure (IOP) and mean defect depth (MD) were collected. Moreover, HSAT results were compared across four phenotypic groups: primary open angle glaucoma (POAG), low-tension-glaucoma (LTG), ocular hypertension (OH), and controls. RESULTS: There was no strong correlation between IOP or MD and AHI. BMI, age and gender did not differ between groups. Significant differences between POAG and LTG were found for all HSAT parameters. The AHI showed the most prominent group difference (Wilcoxon-Kruskal-Wallis rank sum test was highly significant with chi2 = 22, df = 3 p < 0.0001) with severely lower event rates in the LTG (9.45/h) compared to POAG (22.7/h) and controls (21.9/h; p < 0.0001 and 0.02, respectively). Highly significant differences were found between the four groups regarding AHI (Chi2 = 22, df = 3, p < 0.0001) with significantly lower events per hour in the LTG compared to POAG (Hodges-Lehmann = - 13.8, 95% CI (- 18.6 - - 8.8; p < 0.0001) and to controls (Hodges-Lehmann = 12.1, 95% CI -19.9 - - 2.4; p < 0.02). Severe and moderate OSA was more prevalent in POAG (69.8%) and OH (33.3%) than in LTG (9%). The effect of the glaucoma phenotype on the AHI was more prominent in females (p = 0.0006) than in males (p = 0.011). CONCLUSION: Although physical endpoints, such as MD and IOP, do not correlate with AHI, there was a strong correlation between the POAG and OH clinical glaucoma phenotypes and the AHI. Further studies should investigate the necessity to test routine screening for OSA by HSAT in patients with diagnosed POAG and OH. Besides, some characteristics of LTG differed widely from other glaucoma types and controls. LTG patients had a significantly lower rate of OSA compared to other glaucoma types and even controls. This might be due to a different pathogenesis of LTG. TRIAL REGISTRATION: Retrospectively registered at DRKS ( nr. S00021201 ) on April 9th 2020.

Date of acceptance

2020

Autoren

Katharina Bahr
Michael Bopp
Waeel Kewader
Henri Dootz
Julia Döge
Tilman Huppertz
Perikles Simon
Verena Prokosch-Willing
Christoph Matthias
Haralampos Gouveris

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/33032589

DOI

10.1186/s12931-020-01533-7

eISSN

1465-993X

Externe Identifier

PubMed Central ID: PMC7545869

Ausgabe der Veröffentlichung

Zeitschrift

Respir Res

Schlüsselwörter

Glaucoma
Obstructive sleep apnea
Primary open angle glaucoma
Sleep-disordered breathing
Aged
Female
Glaucoma, Open-Angle
Humans
Male
Middle Aged
Ocular Hypertension
Pilot Projects
Retrospective Studies
Risk Factors
Sleep Apnea, Obstructive

Sprache

eng

Country

England

Paginierung

258

PII

10.1186/s12931-020-01533-7

Datum der Veröffentlichung

2020

Status

Published online

Datum, an dem der Datensatz öffentlich gemacht wurde

2021

Titel

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study.

Sub types

Clinical Trial
Journal Article

Ausgabe der Zeitschrift

Datenquelle: PubMed

Author's licence

CC-BY

Autoren

Katharina Bahr
Michael Bopp
Waeel Kewader
Henri Dootz
Julia Döge
Tilman Huppertz
Perikles Simon
Verena Prokosch-Willing
Christoph Matthias
Haralampos Gouveris

Hosting institution

Universitätsbibliothek Mainz

Sammlungen

JGU-Publikationen

Resource version

Published version

DOI

10.1186/s12931-020-01533-7

File(s) embargoed

false

Open access

true

ISSN

1465-993X

Zeitschrift

Respiratory research

Schlüsselwörter

610 Medizin
610 Medical sciences

Sprache

eng

Open access status

Open Access

Paginierung

258

Datum der Veröffentlichung

2020

Public URL

https://openscience.ub.uni-mainz.de/handle/20.500.12030/5845

Herausgeber

BioMed Central

Herausgeber URL

https://doi.org/10.1186/s12931-020-01533-7

Datum der Datenerfassung

2021

Datum, an dem der Datensatz öffentlich gemacht wurde

2021

Zugang

Public

Titel

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study

Ausgabe der Zeitschrift

Files

bahr_katharina-obstructive_sl-20210426113658211.pdf

Datenquelle: OPENSCIENCE.UB

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Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study

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