Wheat Consumption Leads to Immune Activation and Symptom Worsening in Patients with Familial Mediterranean Fever: A Pilot Randomized Trial

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:p>We have identified a clinical association between self-reported non-celiac wheat sensitivity (NCWS) and Familial Mediterranean Fever (FMF). Objectives: A) To determine whether a 2-week double-blind placebo-controlled (DBPC) cross-over wheat vs. rice challenge exacerbates the clinical manifestations of FMF; B) to evaluate innate immune responses in NCWS/FMF patients challenged with wheat vs. rice. The study was conducted at the Department of Internal Medicine of the University Hospital of Palermo and the Hospital of Sciacca, Italy. Six female volunteers with FMF/NCWS (mean age 36 ± 6 years) were enrolled, 12 age-matched non-FMF, NCWS females, and 8 sex- and age-matched healthy subjects served as controls. We evaluated: 1. clinical symptoms by the FMF-specific AIDAI (Auto-Inflammatory Diseases Activity Index) score; 2. serum soluble CD14 (sCD14), C-reactive protein (CRP), and serum amyloid A (SSA); 3. circulating CD14+ monocytes expressing interleukin (IL)-1β and tumor necrosis factor (TNF)-α. The AIDAI score significantly increased in FMF patients during DBPC with wheat, but not with rice (19 ± 6.3 vs. 7 ± 1.6; p = 0.028). sCD14 values did not differ in FMF patients before and after the challenge, but were higher in FMF patients than in healthy controls (median values 11357 vs. 8710 pg/ml; p = 0.002). The percentage of circulating CD14+/IL-1β+ and of CD14+/TNF-α+ monocytes increased significantly after DBPC with wheat vs. baseline or rice challenge. Self-reported NCWS can hide an FMF diagnosis. Wheat ingestion exacerbated clinical and immunological features of FMF. Future studies performed on consecutive FMF patients recruited in centers for auto-inflammatory diseases will determine the real frequency and relevance of this association.</jats:p>
Autoren
  • Antonio Carroccio
  • Pasquale Mansueto
  • Maurizio Soresi
  • Francesca Fayer
  • Diana Di Liberto
  • Erika Monguzzi
  • Marianna Lo Pizzo
  • Francesco La Blasca
  • Girolamo Geraci
  • Alice Pecoraro
  • Francesco Dieli
  • Detlef Schuppan
DOI
10.3390/nu12041127
eISSN
2072-6643
Ausgabe der Veröffentlichung
4
Zeitschrift
Nutrients
Sprache
en
Online publication date
2020
Paginierung
1127 - 1127
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/nu12041127
Datum der Datenerfassung
2020
Titel
Wheat Consumption Leads to Immune Activation and Symptom Worsening in Patients with Familial Mediterranean Fever: A Pilot Randomized Trial
Ausgabe der Zeitschrift
12

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Antonio Carroccio
  • Pasquale Mansueto
  • Maurizio Soresi
  • Francesca Fayer
  • Diana Di Liberto
  • Erika Monguzzi
  • Marianna Lo Pizzo
  • Francesco La Blasca
  • Girolamo Geraci
  • Alice Pecoraro
  • Francesco Dieli
  • Detlef Schuppan
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.3390/nu12041127
Funding acknowledgements
  • DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
2072-6643
Ausgabe der Veröffentlichung
4
Zeitschrift
Nutrients
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
Art. 1127
Datum der Veröffentlichung
2020
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/5232
Herausgeber
MDPI
Herausgeber URL
https://doi.org/10.3390/nu12041127
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Wheat consumption leads to immune activation and symptom worsening in patients with familial mediterranean fever : a pilot randomized trial
Ausgabe der Zeitschrift
12

Files

carroccio_antonio-wheat_consumpt-20201026094104495.pdf

Datenquelle: OPENSCIENCE.UB

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