Incidental Finding of Strut Malapposition Is a Predictor of Late and Very Late Thrombosis in Coronary Bioresorbable Scaffolds

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:p>Malapposition is a common finding in stent and scaffold thrombosis (ScT). Evidence from studies with prospective follow-up, however, is scarce. We hypothesized that incidental observations of strut malapposition might be predictive of late ScT during subsequent follow-up. One hundred ninety-seven patients were enrolled in a multicentre registry with prospective follow-up. Optical coherence tomography (OCT), performed in an elective setting, was available in all at 353 (0–376) days after bioresorbable scaffold (BRS) implantation. Forty-four patients showed evidence of malapposition that was deemed not worthy of intervention. Malapposition was not associated with any clinical or procedural parameter except for a higher implantation pressure (p = 0.0008). OCT revealed that malapposition was associated with larger vessel size, less eccentricity (all p &lt; 0.01), and a tendency for more uncovered struts (p = 0.06). Late or very late ScT was recorded in seven of these patients 293 (38–579) days after OCT. OCT-diagnosed malapposition was a predictor of late and very late scaffold thrombosis (p &lt; 0.001) that was independent of the timing of diagnosis. We provide evidence that an incidental finding of malapposition—regardless of the timing of diagnosis of the malapposition—during an elective exam is a predictor of late and very late ScT. Our data provide a rationale to consider prolonged dual antiplatelet therapy if strut malapposition is observed.</jats:p>
Autoren
  • Niklas F Boeder
  • Melissa Weissner
  • Florian Blachutzik
  • Helen Ullrich
  • Remzi Anadol
  • Monique Tröbs
  • Thomas Münzel
  • Christian W Hamm
  • Jouke Dijkstra
  • Stephan Achenbach
  • Holger M Nef
  • Tommaso Gori
DOI
10.3390/jcm8050580
eISSN
2077-0383
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of Clinical Medicine
Sprache
en
Online publication date
2019
Paginierung
580 - 580
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/jcm8050580
Datum der Datenerfassung
2019
Titel
Incidental Finding of Strut Malapposition Is a Predictor of Late and Very Late Thrombosis in Coronary Bioresorbable Scaffolds
Ausgabe der Zeitschrift
8

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Niklas F Boeder
  • Melissa Weissner
  • Florian Blachutzik
  • Helen Ullrich
  • Remzi Anadol
  • Monique Tröbs
  • Thomas Münzel
  • Christian W Hamm
  • Jouke Dijkstra
  • Stephan Achenbach
  • Holger M Nef
  • Tommaso Gori
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
URN
urn:nbn:de:hebis:77-publ-591366
DOI
10.3390/jcm8050580
Funding acknowledgements
  • DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
2077-0383
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of Clinical Medicine
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
Art. 580
Datum der Veröffentlichung
2019
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/170
Herausgeber
MDPI
Herausgeber URL
http://dx.doi.org/10.3390/jcm8050580
Datum der Datenerfassung
2019
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Zugang
Public
Titel
Incidental finding of strut malapposition is a predictor of late and very late thrombosis in coronary bioresorbable scaffolds
Ausgabe der Zeitschrift
8

Files

59136.pdf

Datenquelle: OPENSCIENCE.UB

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