Molekulare Zellbiologie 2

Beziehungen:

Teil von

• Institut für Molekulare Physiologie

Besitzt Publikation

Die Publikationsliste für die Kategorie "Organisationseinheit" zeigt alle Publikationen, die der einzelnen Organisationseinheit direkt zugeordnet sind. Für eine Liste, die auch alle Publikationen von untergeordneten Organisationseinheiten inkludiert, nutzen Sie die Liste in der Facette "Organisationseinheit".

• Hormone-Inducible Transport Reporter Assay to Study Nuclear Import Defects in Neurodegenerative Diseases
• Sedimentation Assays to Assess the Impact of Posttranslational Modifications on Phase Separation of RNA-Binding Proteins In Vitro and In Cells
• A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptides in Semi-permeabilized Human Cells
• Molecular mechanisms of neurodegeneration
• Nonclassical nuclear localization signals mediate nuclear import of CIRBP
• Creating overview and summary figures
• Only solid waste, please!
• Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants
• Editorial: The Role of Protein Post-Translational Modifications in Protein-RNA Interactions and RNP Assemblies
• Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation
• Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation
• PURA Syndrome-causing mutations impair PUR-domain integrity and affect P-body association
• Innate and adaptive immunity through autophagy
• Endogenous MHC class II processing of a viral nuclear antigen after autophagy
• The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis
• Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
• Nucleocytoplasmic transport defects in neurodegeneration - Cause or consequence?
• Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis
• Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo
• Liquid-Liquid Phase Separation in Disease
• Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function
• Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
• TDP-43 and FUS en route from the nucleus to the cytoplasm
• Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD
• Interaction modulation through arrays of clustered methyl-arginine protein modifications
• Adding intrinsically disordered proteins to biological ageing clocks
• The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors
• FG-nucleoporins caught in the act of liquid-liquid phase separation
• Lysine/RNA-interactions drive and regulate biomolecular condensation
• hnRNPA2/B1 Function in Neurodegeneration: It's a Gain, Not a Loss
• Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
• Interaction modulation through arrays of clustered methyl-arginine protein modifications
• RAN translation down
• Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?
• Friend or foePost-translational modifications as regulators of phase separation and RNP granule dynamics
• The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation
• Altered mRNP granule dynamics in FTLD pathogenesis
• FUScinating insights into motor neuron degeneration
• Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS
• Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration
• Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila
• Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
• Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma
• Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
• Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
• TDP-43 and FUS: a nuclear affair
• FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
• Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
• Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes
• ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
• Localization and MHC Class II Presentation of Antigens Targeted for Macroautophagy
• β-amyloid is a substrate of autophagy in sporadic inclusion body myositis
• Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
• Immune surveillance via self digestion
• Autophagy in innate and adaptive immunity against intracellular pathogens
• Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
• TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury
• Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons
• Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation