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7083. Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

7084. Machine learning meets pKa

7088. 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19

7089. Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain