Exosomes in Cancer Progression and Therapy Resistance: Molecular Insights and Therapeutic Opportunities
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Abstract
- <jats:p>The development of therapy resistance still represents a major hurdle in treating cancers, leading to impaired treatment success and increased patient morbidity. The establishment of minimally invasive liquid biopsies is a promising approach to improving the early diagnosis, as well as therapy monitoring, of solid tumors. Because of their manifold functions in the tumor microenvironment, tumor-associated small extracellular vesicles, referred to as exosomes, have become a subject of intense research. Besides their important roles in cancer progression, metastasis, and the immune response, it has been proposed that exosomes also contribute to the acquisition and transfer of therapy resistance, mainly by delivering functional proteins and RNAs, as well as facilitating the export of active drugs or functioning as extracellular decoys. Extensive research has focused on understanding the molecular mechanisms underlying the occurrence of resistance and translating these into strategies for early detection. With this review, we want to provide an overview of the current knowledge about the (patho-)biology of exosomes, as well as state-of-the-art methods of isolation and analysis. Furthermore, we highlight the role of exosomes in tumorigenesis and cancer treatment, where they can function as therapeutic agents, biomarkers, and/or targets. By focusing on their roles in therapy resistance, we will reveal new paths of exploiting exosomes for cancer diagnosis and treatment.</jats:p>
- Autoren
- Madita Wandrey
- Jadwiga Jablonska
- Roland H Stauber
- Désirée Gül
- DOI
- 10.3390/life13102033
- eISSN
- 2075-1729
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Life
- Sprache
- en
- Online publication date
- 2023
- Paginierung
- 2033 - 2033
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/life13102033
- Datum der Datenerfassung
- 2023
- Titel
- Exosomes in Cancer Progression and Therapy Resistance: Molecular Insights and Therapeutic Opportunities
- Ausgabe der Zeitschrift
- 13
Datenquelle: Crossref
- Andere Metadatenquellen:
-
- Author's licence
- CC-BY
- Autoren
- Madita Wandrey
- Jadwiga Jablosnka
- Roland H Stauber
- Désirée Gül
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-491381577-G
- Resource version
- Published version
- DOI
- 10.3390/life13102033
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2075-1729
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Life
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 2033
- Datum der Veröffentlichung
- 2023
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/10083
- Herausgeber
- MDPI
- Datum der Datenerfassung
- 2024
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2024
- Zugang
- Public
- Titel
- Exosomes in cancer progression and therapy resistance : molecular insights and therapeutic opportunities
- Ausgabe der Zeitschrift
- 13
Files
exosomes_in_cancer_progressio-20240207173746445.pdf
Datenquelle: OPENSCIENCE.UB