Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- David J Michalak
- Shoujun Xu
- Thomas J Lowery
- CW Crawford
- Micah Ledbetter
- Louis-S Bouchard
- David E Wemmer
- Dmitry Budker
- Alexander Pines
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000293256800033&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/mrm.22811
- Externe Identifier
- Clarivate Analytics Document Solution ID: 799AV
- PubMed Identifier: 21433067
- ISSN
- 0740-3194
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- MAGNETIC RESONANCE IN MEDICINE
- Schlüsselwörter
- atomic magnetometry
- relaxivity
- gadolinium
- Paginierung
- 605 - 608
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Titel
- Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry
- Sub types
- Article
- Ausgabe der Zeitschrift
- 66
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Laser atomic magnetometry is a portable and low‐cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote‐detection geometry to measure the relaxivity of aqueous gadolinium‐diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7 ± 2.0 s<jats:sup>−1</jats:sup> mM<jats:sup>−1</jats:sup> is consistent with field‐cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field‐independent sensitivity of 80 fT Hz<jats:sup>–1/2</jats:sup> allowed an in vitro detection limit of ∼ 10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd‐containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications. Magn Reson Med 66:603–606, 2011. © 2011 Wiley‐Liss, Inc.</jats:p>
- Autoren
- David J Michalak
- Shoujun Xu
- Thomas J Lowery
- CW Crawford
- Micah Ledbetter
- Louis‐S Bouchard
- David E Wemmer
- Dmitry Budker
- Alexander Pines
- DOI
- 10.1002/mrm.22811
- eISSN
- 1522-2594
- ISSN
- 0740-3194
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Magnetic Resonance in Medicine
- Sprache
- en
- Online publication date
- 2011
- Paginierung
- 603 - 606
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/mrm.22811
- Datum der Datenerfassung
- 2023
- Titel
- Relaxivity of gadolinium complexes detected by atomic magnetometry
- Ausgabe der Zeitschrift
- 66
Datenquelle: Crossref
- Abstract
- Laser atomic magnetometry is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7±2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of ∼10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications.
- Addresses
- Materials Sciences Division, Lawrence Berkeley National Laboratory, Department of Chemistry, University of California, Berkeley, California, USA.
- Autoren
- David J Michalak
- Shoujun Xu
- Thomas J Lowery
- CW Crawford
- Micah Ledbetter
- Louis-S Bouchard
- David E Wemmer
- Dmitry Budker
- Alexander Pines
- DOI
- 10.1002/mrm.22811
- eISSN
- 1522-2594
- Externe Identifier
- PubMed Identifier: 21433067
- Funding acknowledgements
- Nuclear Sciences Division of the U.S. Department of Energy:
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering: DE-AC02-05CH11231
- ONR MURI grant:
- Open access
- false
- ISSN
- 0740-3194
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Magnetic resonance in medicine
- Schlüsselwörter
- Gadolinium
- Contrast Media
- Magnetic Resonance Spectroscopy
- Sensitivity and Specificity
- Reproducibility of Results
- Equipment Design
- Equipment Failure Analysis
- Drug Evaluation, Preclinical
- Magnetometry
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Paginierung
- 605 - 608
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Relaxivity of gadolinium complexes detected by atomic magnetometry.
- Sub types
- Research Support, U.S. Gov't, Non-P.H.S.
- Journal Article
- Ausgabe der Zeitschrift
- 66
Datenquelle: Europe PubMed Central
- Abstract
- Laser atomic magnetometry is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7±2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of ∼10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications.
- Date of acceptance
- 2010
- Autoren
- David J Michalak
- Shoujun Xu
- Thomas J Lowery
- CW Crawford
- Micah Ledbetter
- Louis-S Bouchard
- David E Wemmer
- Dmitry Budker
- Alexander Pines
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21433067
- DOI
- 10.1002/mrm.22811
- eISSN
- 1522-2594
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Magn Reson Med
- Schlüsselwörter
- Contrast Media
- Drug Evaluation, Preclinical
- Equipment Design
- Equipment Failure Analysis
- Gadolinium
- Magnetic Resonance Spectroscopy
- Magnetometry
- Reproducibility of Results
- Sensitivity and Specificity
- Sprache
- eng
- Country
- United States
- Paginierung
- 605 - 608
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Relaxivity of gadolinium complexes detected by atomic magnetometry.
- Sub types
- Journal Article
- Research Support, U.S. Gov't, Non-P.H.S.
- Ausgabe der Zeitschrift
- 66
Datenquelle: PubMed
- Beziehungen:
- Eigentum von