Probing the Folding of Peptide–Polymer Conjugates Using the π-Dimerization of Viologen End-Groups
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
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- Abstract
- <jats:p>The synthesis of a foldable viologen-functionalized peptide–polymer conjugate is presented. The ABA-type triblock conjugate with a PEG polymer was capped with a FHFHF pentapeptide sequence and further modified with a viologen building block at both chain ends. The pH-responsive peptide domains fold into an intermediate structure inducing close proximity of the viologen units, which upon a reduction step form π-dimers of the radical cation. Overall the intramolecular folding and intermolecular self-assembly process leads to the formation of supramolecular nanorods. Mixing of viologen-peptide–polymer conjugates with unfunctionalized conjugates leads to crosslinking of the nanorods and hydrogels with a tunable content of viologen end groups. π-Dimerization in the gels induces a deep purple color, which is used as an optical probe to monitor the diffusion of molecular oxygen through the hydrogel matrix.</jats:p>
- Autoren
- Ronja Otter
- Pol Besenius
- DOI
- 10.1055/s-0040-1710343
- eISSN
- 2625-1825
- Ausgabe der Veröffentlichung
- 02
- Zeitschrift
- Organic Materials
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 143 - 148
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Georg Thieme Verlag KG
- Herausgeber URL
- http://dx.doi.org/10.1055/s-0040-1710343
- Datum der Datenerfassung
- 2021
- Titel
- Probing the Folding of Peptide–Polymer Conjugates Using the π-Dimerization of Viologen End-Groups
- Ausgabe der Zeitschrift
- 02
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