Tailored Polymer-Supported Templates in Dynamic Combinatorial Libraries: Simultaneous Selection, Amplification and Isolation of Synthetic Receptors

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Pol Besenius
  • Peter AG Cormack
  • Jingyuan Liu
  • Sijbren Otto
  • Jeremy KM Sanders
  • David C Sherrington
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000260278900034&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/chem.200800326
eISSN
1521-3765
Externe Identifier
  • Clarivate Analytics Document Solution ID: 363PJ
  • PubMed Identifier: 18752246
ISSN
0947-6539
Ausgabe der Veröffentlichung
29
Zeitschrift
CHEMISTRY-A EUROPEAN JOURNAL
Schlüsselwörter
  • affinity chromatography
  • dynamic combinatorial chemistry
  • molecular recognition
  • polymer-supported templates
  • synthetic receptors
Paginierung
9006 - 9019
Datum der Veröffentlichung
2008
Status
Published
Titel
Tailored Polymer-Supported Templates in Dynamic Combinatorial Libraries: Simultaneous Selection, Amplification and Isolation of Synthetic Receptors
Sub types
  • Article
Ausgabe der Zeitschrift
14

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:title>Abstract</jats:title><jats:p>The thermodynamically controlled synthesis and isolation of macrocyclic receptors from dynamic combinatorial libraries has been achieved in a single step using a polymer‐supported template. The templates were cinchona alkaloids which show interesting enantio‐ and diastereoselective molecular recognition events in libraries based on pseudo‐dipeptide building blocks. The synthetic routes used to derivatise the alkaloids and attach them to polymer supports minimised any influence of the tethering linkage on the templating activity. Systematic studies have been carried out to probe how the polymer morphology and the template loading affect the selectivity and isolation yield of the macrocyclic receptors. Molecular recognition between solid‐phase bound templates and selected receptors also enabled their affinity‐type chromatographic separation.</jats:p>
Autoren
  • Pol Besenius
  • Peter AG Cormack
  • Jingyuan Liu
  • Sijbren Otto
  • Jeremy KM Sanders
  • David C Sherrington
DOI
10.1002/chem.200800326
eISSN
1521-3765
ISSN
0947-6539
Ausgabe der Veröffentlichung
29
Zeitschrift
Chemistry – A European Journal
Sprache
en
Online publication date
2008
Paginierung
9006 - 9019
Datum der Veröffentlichung
2008
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/chem.200800326
Datum der Datenerfassung
2023
Titel
Tailored Polymer‐Supported Templates in Dynamic Combinatorial Libraries: Simultaneous Selection, Amplification and Isolation of Synthetic Receptors
Ausgabe der Zeitschrift
14

Datenquelle: Crossref

Abstract
The thermodynamically controlled synthesis and isolation of macrocyclic receptors from dynamic combinatorial libraries has been achieved in a single step using a polymer-supported template. The templates were cinchona alkaloids which show interesting enantio- and diastereoselective molecular recognition events in libraries based on pseudo-dipeptide building blocks. The synthetic routes used to derivatise the alkaloids and attach them to polymer supports minimised any influence of the tethering linkage on the templating activity. Systematic studies have been carried out to probe how the polymer morphology and the template loading affect the selectivity and isolation yield of the macrocyclic receptors. Molecular recognition between solid-phase bound templates and selected receptors also enabled their affinity-type chromatographic separation.
Addresses
  • WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL (UK), Fax: (+44) 141-548-4246.
Autoren
  • Pol Besenius
  • Peter AG Cormack
  • Jingyuan Liu
  • Sijbren Otto
  • Jeremy KM Sanders
  • David C Sherrington
DOI
10.1002/chem.200800326
eISSN
1521-3765
Externe Identifier
  • PubMed Identifier: 18752246
Funding acknowledgements
  • Engineering and Physical Sciences Research Council: GR/S76908/01
  • EPSRC:
  • Royal Society:
Open access
false
ISSN
0947-6539
Ausgabe der Veröffentlichung
29
Zeitschrift
Chemistry (Weinheim an der Bergstrasse, Germany)
Schlüsselwörter
  • Cinchona Alkaloids
  • Polymers
  • Microscopy, Electron, Transmission
  • Chromatography, High Pressure Liquid
  • Combinatorial Chemistry Techniques
  • Molecular Structure
  • Surface Properties
Sprache
eng
Medium
Print
Paginierung
9006 - 9019
Datum der Veröffentlichung
2008
Status
Published
Datum der Datenerfassung
2008
Titel
Tailored polymer-supported templates in dynamic combinatorial libraries: simultaneous selection, amplification and isolation of synthetic receptors.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
14

Datenquelle: Europe PubMed Central

Abstract
The thermodynamically controlled synthesis and isolation of macrocyclic receptors from dynamic combinatorial libraries has been achieved in a single step using a polymer-supported template. The templates were cinchona alkaloids which show interesting enantio- and diastereoselective molecular recognition events in libraries based on pseudo-dipeptide building blocks. The synthetic routes used to derivatise the alkaloids and attach them to polymer supports minimised any influence of the tethering linkage on the templating activity. Systematic studies have been carried out to probe how the polymer morphology and the template loading affect the selectivity and isolation yield of the macrocyclic receptors. Molecular recognition between solid-phase bound templates and selected receptors also enabled their affinity-type chromatographic separation.
Autoren
  • Pol Besenius
  • Peter AG Cormack
  • Jingyuan Liu
  • Sijbren Otto
  • Jeremy KM Sanders
  • David C Sherrington
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/18752246
DOI
10.1002/chem.200800326
ISSN
0947-6539
Ausgabe der Veröffentlichung
29
Zeitschrift
Chemistry
Schlüsselwörter
  • Chromatography, High Pressure Liquid
  • Cinchona Alkaloids
  • Combinatorial Chemistry Techniques
  • Microscopy, Electron, Transmission
  • Molecular Structure
  • Polymers
  • Surface Properties
Sprache
eng
Country
Germany
Paginierung
9006 - 9019
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
Tailored polymer-supported templates in dynamic combinatorial libraries: simultaneous selection, amplification and isolation of synthetic receptors.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
14

Datenquelle: PubMed

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