Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000347229500010&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1039/c4ob02185a
eISSN
1477-0539
Externe Identifier
  • Clarivate Analytics Document Solution ID: AX9NO
  • PubMed Identifier: 25410414
ISSN
1477-0520
Ausgabe der Veröffentlichung
4
Zeitschrift
ORGANIC & BIOMOLECULAR CHEMISTRY
Paginierung
1030 - 1039
Datum der Veröffentlichung
2015
Status
Published
Titel
Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains
Sub types
  • Article
Ausgabe der Zeitschrift
13

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<p>We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character and describe their self-assembly into supramolecular nanorods using pH and ionic strength dependent state diagrams.</p>
Autoren
DOI
10.1039/c4ob02185a
eISSN
1477-0539
ISSN
1477-0520
Ausgabe der Veröffentlichung
4
Zeitschrift
Organic &amp; Biomolecular Chemistry
Sprache
en
Online publication date
2015
Paginierung
1030 - 1039
Status
Published online
Herausgeber
Royal Society of Chemistry (RSC)
Herausgeber URL
http://dx.doi.org/10.1039/c4ob02185a
Datum der Datenerfassung
2024
Titel
Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains
Ausgabe der Zeitschrift
13

Datenquelle: Crossref

Abstract
We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character. By establishing state diagrams we describe their pH and ionic strength triggered self-assembly into supramolecular nanorods in water and highlight the impact of hydrophobic shielding in the supramolecular polymerisation process. Via the incorporation of fluorinated peptide side chains the pH-triggered monomer to polymer transition at physiological ionic strength is shifted from pH 5.0 to pH 7.4. We thereby show that compensating attractive non-covalent interactions and hydrophobic effects with repulsive electrostatic forces, a concept we refer to as frustrated growth, is a sensitive tool in order to manipulate one-dimensional supramolecular polymerisation processes in water.
Addresses
  • Organic Chemistry Institute, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany. p.besenius@uni-muenster.de.
Autoren
DOI
10.1039/c4ob02185a
eISSN
1477-0539
Externe Identifier
  • PubMed Identifier: 25410414
Open access
false
ISSN
1477-0520
Ausgabe der Veröffentlichung
4
Zeitschrift
Organic & biomolecular chemistry
Schlüsselwörter
  • Water
  • Peptides
  • Hydrogen-Ion Concentration
  • Osmolar Concentration
  • Nanotubes
  • Dendrimers
  • Halogenation
  • Static Electricity
  • Hydrophobic and Hydrophilic Interactions
  • Polymerization
Sprache
eng
Medium
Print-Electronic
Online publication date
2014
Paginierung
1030 - 1039
Datum der Veröffentlichung
2015
Status
Published
Datum der Datenerfassung
2014
Titel
Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
13

Datenquelle: Europe PubMed Central

Abstract
We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character. By establishing state diagrams we describe their pH and ionic strength triggered self-assembly into supramolecular nanorods in water and highlight the impact of hydrophobic shielding in the supramolecular polymerisation process. Via the incorporation of fluorinated peptide side chains the pH-triggered monomer to polymer transition at physiological ionic strength is shifted from pH 5.0 to pH 7.4. We thereby show that compensating attractive non-covalent interactions and hydrophobic effects with repulsive electrostatic forces, a concept we refer to as frustrated growth, is a sensitive tool in order to manipulate one-dimensional supramolecular polymerisation processes in water.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/25410414
DOI
10.1039/c4ob02185a
eISSN
1477-0539
Ausgabe der Veröffentlichung
4
Zeitschrift
Org Biomol Chem
Schlüsselwörter
  • Dendrimers
  • Halogenation
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Nanotubes
  • Osmolar Concentration
  • Peptides
  • Polymerization
  • Static Electricity
  • Water
Sprache
eng
Country
England
Paginierung
1030 - 1039
Datum der Veröffentlichung
2015
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2015
Titel
Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
13

Datenquelle: PubMed

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