Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- David Strassburger
- Natascha Stergiou
- Moritz Urschbach
- Hajime Yurugi
- Daniel Spitzer
- Dieter Schollmeyer
- Edgar Schmitt
- Pol Besenius
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000431625100004&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/cbic.201800114
- eISSN
- 1439-7633
- Externe Identifier
- Clarivate Analytics Document Solution ID: GF0MN
- PubMed Identifier: 29486092
- ISSN
- 1439-4227
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- CHEMBIOCHEM
- Schlüsselwörter
- amphiphiles
- peptides
- polymers
- self-assembly
- supramolecular chemistry
- Paginierung
- 912 - 916
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Titel
- Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 19
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>A modular route to prepare functional self‐assembling dendritic peptide amphiphiles decorated with mannosides, to effectively target antigen‐presenting cells, such as macrophages, is reported. The monomeric building blocks were equipped with tetra(ethylene glycol)s (TEGs) or labeled with a Cy3 fluorescent probe. Experiments on the uptake of the multifunctional supramolecular particles into murine macrophages (Mφs) were monitored by confocal microscopy and fluorescence‐activated cell sorting. Mannose‐decorated supramolecular polymers trigger a significantly higher cellular uptake and distribution, relative to TEG carrying bare polymers. No cytotoxicity or negative impact on cytokine production of the treated Mφs was observed, which emphasized their biocompatibility. The modular nature of the multicomponent supramolecular polymer coassembly protocol is a promising platform to develop fully synthetic multifunctional vaccines, for example, in cancer immunotherapy.</jats:p>
- Autoren
- David Straßburger
- Natascha Stergiou
- Moritz Urschbach
- Hajime Yurugi
- Daniel Spitzer
- Dieter Schollmeyer
- Edgar Schmitt
- Pol Besenius
- DOI
- 10.1002/cbic.201800114
- eISSN
- 1439-7633
- ISSN
- 1439-4227
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- ChemBioChem
- Sprache
- en
- Online publication date
- 2018
- Paginierung
- 912 - 916
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/cbic.201800114
- Datum der Datenerfassung
- 2023
- Titel
- Mannose‐Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen‐Presenting Cells
- Ausgabe der Zeitschrift
- 19
Datenquelle: Crossref
- Abstract
- A modular route to prepare functional self-assembling dendritic peptide amphiphiles decorated with mannosides, to effectively target antigen-presenting cells, such as macrophages, is reported. The monomeric building blocks were equipped with tetra(ethylene glycol)s (TEGs) or labeled with a Cy3 fluorescent probe. Experiments on the uptake of the multifunctional supramolecular particles into murine macrophages (Mφs) were monitored by confocal microscopy and fluorescence-activated cell sorting. Mannose-decorated supramolecular polymers trigger a significantly higher cellular uptake and distribution, relative to TEG carrying bare polymers. No cytotoxicity or negative impact on cytokine production of the treated Mφs was observed, which emphasized their biocompatibility. The modular nature of the multicomponent supramolecular polymer coassembly protocol is a promising platform to develop fully synthetic multifunctional vaccines, for example, in cancer immunotherapy.
- Addresses
- Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
- Autoren
- David Straßburger
- Natascha Stergiou
- Moritz Urschbach
- Hajime Yurugi
- Daniel Spitzer
- Dieter Schollmeyer
- Edgar Schmitt
- Pol Besenius
- DOI
- 10.1002/cbic.201800114
- eISSN
- 1439-7633
- Externe Identifier
- PubMed Identifier: 29486092
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: SFB 1066
- Open access
- false
- ISSN
- 1439-4227
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Chembiochem : a European journal of chemical biology
- Schlüsselwörter
- Antigen-Presenting Cells
- Cells, Cultured
- Macrophages
- Animals
- Mice
- Polyethylene Glycols
- Carbocyanines
- Mannosides
- Peptides
- Fluorescent Dyes
- Surface-Active Agents
- Microscopy, Confocal
- Biological Transport
- Models, Molecular
- Dendrimers
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2018
- Paginierung
- 912 - 916
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Datum der Datenerfassung
- 2018
- Titel
- Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 19
Datenquelle: Europe PubMed Central
- Abstract
- A modular route to prepare functional self-assembling dendritic peptide amphiphiles decorated with mannosides, to effectively target antigen-presenting cells, such as macrophages, is reported. The monomeric building blocks were equipped with tetra(ethylene glycol)s (TEGs) or labeled with a Cy3 fluorescent probe. Experiments on the uptake of the multifunctional supramolecular particles into murine macrophages (Mφs) were monitored by confocal microscopy and fluorescence-activated cell sorting. Mannose-decorated supramolecular polymers trigger a significantly higher cellular uptake and distribution, relative to TEG carrying bare polymers. No cytotoxicity or negative impact on cytokine production of the treated Mφs was observed, which emphasized their biocompatibility. The modular nature of the multicomponent supramolecular polymer coassembly protocol is a promising platform to develop fully synthetic multifunctional vaccines, for example, in cancer immunotherapy.
- Autoren
- David Straßburger
- Natascha Stergiou
- Moritz Urschbach
- Hajime Yurugi
- Daniel Spitzer
- Dieter Schollmeyer
- Edgar Schmitt
- Pol Besenius
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29486092
- DOI
- 10.1002/cbic.201800114
- eISSN
- 1439-7633
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Chembiochem
- Schlüsselwörter
- amphiphiles
- peptides
- polymers
- self-assembly
- supramolecular chemistry
- Animals
- Antigen-Presenting Cells
- Biological Transport
- Carbocyanines
- Cells, Cultured
- Dendrimers
- Fluorescent Dyes
- Macrophages
- Mannosides
- Mice
- Microscopy, Confocal
- Models, Molecular
- Peptides
- Polyethylene Glycols
- Surface-Active Agents
- Sprache
- eng
- Country
- Germany
- Paginierung
- 912 - 916
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 19
Datenquelle: PubMed
- Beziehungen:
-