Construction of Active Protein Materials: Manipulation on Morphology of Salmon Calcitonin Assemblies with Enhanced Bone Regeneration Effect
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Libin Wu
- Liang Cheng
- Jing Yang
- Yufei Yan
- Ensong Zhang
- Zdravko Kochovski
- Long Li
- Zhen Wang
- Lianfu Deng
- Yan Lu
- Pol Besenius
- Wenguo Cui
- Guosong Chen
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000865234000001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/adma.202207526
- eISSN
- 1521-4095
- Externe Identifier
- Clarivate Analytics Document Solution ID: 6A4YL
- PubMed Identifier: 36103707
- ISSN
- 0935-9648
- Ausgabe der Veröffentlichung
- 45
- Zeitschrift
- ADVANCED MATERIALS
- Schlüsselwörter
- active protein materials
- bone regeneration
- morphology manipulation
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Construction of Active Protein Materials: Manipulation on Morphology of Salmon Calcitonin Assemblies with Enhanced Bone Regeneration Effect
- Sub types
- Article
- Ausgabe der Zeitschrift
- 34
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>The effect of protein drugs is always limited by their relatively low stability and fast degradation property; thus, various elegant efforts have been made to improve the bioactivity and biocompatibility of the protein drugs. Here, an alternative way is proposed to solve this problem. By simply adding a limited amount of small‐molecular regulator, which tunes the subtle balance of protein–protein interactions (PPIs) and disulfide bond formation, the self‐assembly property of the protein drug can be regulated, forming an “active protein material” itself. This means that, the resulting biomaterial is dominated by the protein drug and water, with significantly enhanced bone regeneration effect compared to the virgin protein in vitro and in vivo, through multivalent effect between the protein and receptor and the retarded degradation of the assembled proteins. In this active protein material, the protein drug is not only the active drug, but also the drug carrier, which greatly increases the drug‐loading efficiency of the biomaterial, indicating the advantages of the easy preparation, high efficiency, and low cost of the active protein material with a bright future in biomedical applications.</jats:p>
- Autoren
- Libin Wu
- Liang Cheng
- Jing Yang
- Yufei Yan
- Ensong Zhang
- Zdravko Kochovski
- Long Li
- Zhen Wang
- Lianfu Deng
- Yan Lu
- Pol Besenius
- Wenguo Cui
- Guosong Chen
- DOI
- 10.1002/adma.202207526
- eISSN
- 1521-4095
- ISSN
- 0935-9648
- Ausgabe der Veröffentlichung
- 45
- Zeitschrift
- Advanced Materials
- Sprache
- en
- Online publication date
- 2022
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/adma.202207526
- Datum der Datenerfassung
- 2023
- Titel
- Construction of Active Protein Materials: Manipulation on Morphology of Salmon Calcitonin Assemblies with Enhanced Bone Regeneration Effect
- Ausgabe der Zeitschrift
- 34
Datenquelle: Crossref
- Abstract
- The effect of protein drugs is always limited by their relatively low stability and fast degradation property; thus, various elegant efforts have been made to improve the bioactivity and biocompatibility of the protein drugs. Here, an alternative way is proposed to solve this problem. By simply adding a limited amount of small-molecular regulator, which tunes the subtle balance of protein-protein interactions (PPIs) and disulfide bond formation, the self-assembly property of the protein drug can be regulated, forming an "active protein material" itself. This means that, the resulting biomaterial is dominated by the protein drug and water, with significantly enhanced bone regeneration effect compared to the virgin protein in vitro and in vivo, through multivalent effect between the protein and receptor and the retarded degradation of the assembled proteins. In this active protein material, the protein drug is not only the active drug, but also the drug carrier, which greatly increases the drug-loading efficiency of the biomaterial, indicating the advantages of the easy preparation, high efficiency, and low cost of the active protein material with a bright future in biomedical applications.
- Addresses
- The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
- Autoren
- Libin Wu
- Liang Cheng
- Jing Yang
- Yufei Yan
- Ensong Zhang
- Zdravko Kochovski
- Long Li
- Zhen Wang
- Lianfu Deng
- Yan Lu
- Pol Besenius
- Wenguo Cui
- Guosong Chen
- DOI
- 10.1002/adma.202207526
- eISSN
- 1521-4095
- Externe Identifier
- PubMed Identifier: 36103707
- Funding acknowledgements
- National Key Research and Development Program of China: 2022YFB3800124
- National Natural Science Foundation of China: 51721002
- Shanghai Municipal Science and Technology Major Project: 2018SHZDZX01
- NSFC: 91956127
- NSFC: 51721002
- NSFC: 52125303
- Shanghai Municipal Education Commission: 20171906
- Deutsche Forschungsgemeinschaft (DFG) (German Research Foundation): 410871749
- National Natural Science Foundation of China: 52125303
- National Natural Science Foundation of China: 91956127
- ZJ Lab:
- NSFC: 21975047
- National Natural Science Foundation of China: 21975047
- Open access
- false
- ISSN
- 0935-9648
- Ausgabe der Veröffentlichung
- 45
- Zeitschrift
- Advanced materials (Deerfield Beach, Fla.)
- Schlüsselwörter
- Calcitonin
- Biocompatible Materials
- Drug Carriers
- Bone Regeneration
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2022
- Paginierung
- e2207526
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum der Datenerfassung
- 2022
- Titel
- Construction of Active Protein Materials: Manipulation on Morphology of Salmon Calcitonin Assemblies with Enhanced Bone Regeneration Effect.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 34
Datenquelle: Europe PubMed Central
- Abstract
- The effect of protein drugs is always limited by their relatively low stability and fast degradation property; thus, various elegant efforts have been made to improve the bioactivity and biocompatibility of the protein drugs. Here, an alternative way is proposed to solve this problem. By simply adding a limited amount of small-molecular regulator, which tunes the subtle balance of protein-protein interactions (PPIs) and disulfide bond formation, the self-assembly property of the protein drug can be regulated, forming an "active protein material" itself. This means that, the resulting biomaterial is dominated by the protein drug and water, with significantly enhanced bone regeneration effect compared to the virgin protein in vitro and in vivo, through multivalent effect between the protein and receptor and the retarded degradation of the assembled proteins. In this active protein material, the protein drug is not only the active drug, but also the drug carrier, which greatly increases the drug-loading efficiency of the biomaterial, indicating the advantages of the easy preparation, high efficiency, and low cost of the active protein material with a bright future in biomedical applications.
- Autoren
- Libin Wu
- Liang Cheng
- Jing Yang
- Yufei Yan
- Ensong Zhang
- Zdravko Kochovski
- Long Li
- Zhen Wang
- Lianfu Deng
- Yan Lu
- Pol Besenius
- Wenguo Cui
- Guosong Chen
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36103707
- DOI
- 10.1002/adma.202207526
- eISSN
- 1521-4095
- Funding acknowledgements
- NSFC: 52125303
- NSFC: 51721002
- NSFC: 91956127
- NSFC: 21975047
- National Key Research and Development Program of China: 2022YFB3800124
- Shanghai Municipal Education Commission: 20171906
- Shanghai Municipal Science and Technology Major Project: 2018SHZDZX01
- Deutsche Forschungsgemeinschaft (DFG) (German Research Foundation): 410871749
- ZJ Lab:
- Ausgabe der Veröffentlichung
- 45
- Zeitschrift
- Adv Mater
- Schlüsselwörter
- active protein materials
- bone regeneration
- morphology manipulation
- Bone Regeneration
- Biocompatible Materials
- Calcitonin
- Drug Carriers
- Sprache
- eng
- Country
- Germany
- Paginierung
- e2207526
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Construction of Active Protein Materials: Manipulation on Morphology of Salmon Calcitonin Assemblies with Enhanced Bone Regeneration Effect.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 34
Datenquelle: PubMed
- Beziehungen:
-