Diminished production of proinflammatory cytokines in patients with Alzheimer's disease
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- E Richartz
- A Batra
- P Simon
- H Wormstall
- M Bartels
- G Buchkremer
- K Schott
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000227887700002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1159/000083497
- Externe Identifier
- Clarivate Analytics Document Solution ID: 909VB
- PubMed Identifier: 15677865
- ISSN
- 1420-8008
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Schlüsselwörter
- Alzheimer's disease
- proinflammatory cytokines
- peripheral markers
- phagocytosis
- immunosenescence
- Paginierung
- 184 - 188
- Datum der Veröffentlichung
- 2005
- Status
- Published
- Titel
- Diminished production of proinflammatory cytokines in patients with Alzheimer's disease
- Sub types
- Article
- Ausgabe der Zeitschrift
- 19
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Cerebral inflammation as well as systemic immunological alterations have been reported in Alzheimer’s disease (AD). We examined the production of the proinflammatory cytokines interleukin-6, interleukin-12, interferon-γ, and tumor necrosis factor-α in whole blood cell cultures of AD patients and age-matched controls. The production of all measured cytokines after mitogen stimulation is significantly decreased in the AD group compared to controls. The results reflect an attenuated secretory activity of monocytes/macrophages, but also of T-helper cells. The data sustain the assumption that a systemic, possibly age-related alteration of immune mechanisms may play a pathogenetic role in the development of AD.</jats:p>
- Autoren
- E Richartz
- A Batra
- P Simon
- H Wormstall
- M Bartels
- G Buchkremer
- K Schott
- DOI
- 10.1159/000083497
- eISSN
- 1421-9824
- ISSN
- 1420-8008
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Dementia and Geriatric Cognitive Disorders
- Sprache
- en
- Online publication date
- 2005
- Paginierung
- 184 - 188
- Datum der Veröffentlichung
- 2005
- Status
- Published
- Herausgeber
- S. Karger AG
- Herausgeber URL
- http://dx.doi.org/10.1159/000083497
- Datum der Datenerfassung
- 2024
- Titel
- Diminished Production of Proinflammatory Cytokines in Patients with Alzheimer’s Disease
- Ausgabe der Zeitschrift
- 19
Datenquelle: Crossref
- Abstract
- Cerebral inflammation as well as systemic immunological alterations have been reported in Alzheimer's disease (AD). We examined the production of the proinflammatory cytokines interleukin-6, interleukin-12, interferon-gamma, and tumor necrosis factor-alpha in whole blood cell cultures of AD patients and age-matched controls. The production of all measured cytokines after mitogen stimulation is significantly decreased in the AD group compared to controls. The results reflect an attenuated secretory activity of monocytes/macrophages, but also of T-helper cells. The data sustain the assumption that a systemic, possibly age-related alteration of immune mechanisms may play a pathogenetic role in the development of AD.
- Addresses
- Department of Psychiatry and Psychotherapy, University of Tübingen, Osianderstrasse 24, DE-72076 Tübingen, Germany. elke.richartz@med.uni-tuebingen.de
- Autoren
- E Richartz
- A Batra
- P Simon
- H Wormstall
- M Bartels
- G Buchkremer
- K Schott
- DOI
- 10.1159/000083497
- eISSN
- 1421-9824
- Externe Identifier
- PubMed Identifier: 15677865
- Open access
- false
- ISSN
- 1420-8008
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Dementia and geriatric cognitive disorders
- Schlüsselwörter
- Humans
- Alzheimer Disease
- Tumor Necrosis Factor-alpha
- Interleukin-6
- Interleukin-12
- Enzyme-Linked Immunosorbent Assay
- Aged
- Female
- Male
- Interferon-gamma
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2005
- Paginierung
- 184 - 188
- Datum der Veröffentlichung
- 2005
- Status
- Published
- Datum der Datenerfassung
- 2005
- Titel
- Diminished production of proinflammatory cytokines in patients with Alzheimer's disease.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 19
Datenquelle: Europe PubMed Central
- Abstract
- Cerebral inflammation as well as systemic immunological alterations have been reported in Alzheimer's disease (AD). We examined the production of the proinflammatory cytokines interleukin-6, interleukin-12, interferon-gamma, and tumor necrosis factor-alpha in whole blood cell cultures of AD patients and age-matched controls. The production of all measured cytokines after mitogen stimulation is significantly decreased in the AD group compared to controls. The results reflect an attenuated secretory activity of monocytes/macrophages, but also of T-helper cells. The data sustain the assumption that a systemic, possibly age-related alteration of immune mechanisms may play a pathogenetic role in the development of AD.
- Date of acceptance
- 2004
- Autoren
- E Richartz
- A Batra
- P Simon
- H Wormstall
- M Bartels
- G Buchkremer
- K Schott
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/15677865
- DOI
- 10.1159/000083497
- ISSN
- 1420-8008
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Dement Geriatr Cogn Disord
- Schlüsselwörter
- Aged
- Alzheimer Disease
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Interferon-gamma
- Interleukin-12
- Interleukin-6
- Male
- Tumor Necrosis Factor-alpha
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 184 - 188
- PII
- 83497
- Datum der Veröffentlichung
- 2005
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2005
- Titel
- Diminished production of proinflammatory cytokines in patients with Alzheimer's disease.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 19
Datenquelle: PubMed
- Beziehungen:
- Eigentum von