Thy-1 is critical for normal retinal development

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • PD Simon
  • J McConnell
  • D Zurakowski
  • CK Vorwerk
  • R Naskar
  • CL Grosskreutz
  • EB Dreyer
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000083881400011&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/S0165-3806(99)00123-6
Externe Identifier
  • Clarivate Analytics Document Solution ID: 259EK
  • PubMed Identifier: 10567740
ISSN
0165-3806
Ausgabe der Veröffentlichung
2
Zeitschrift
DEVELOPMENTAL BRAIN RESEARCH
Schlüsselwörter
  • retinal ganglion cell
  • Thy-1
  • neurite
  • outgrowth
Paginierung
219 - 223
Datum der Veröffentlichung
1999
Status
Published
Titel
Thy-1 is critical for normal retinal development
Sub types
  • Article
Ausgabe der Zeitschrift
117

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Perikles D Simon
  • Jane McConnell
  • David Zurakowski
  • Christian K Vorwerk
  • Rita Naskar
  • Cynthia L Grosskreutz
  • Evan B Dreyer
DOI
10.1016/s0165-3806(99)00123-6
ISSN
0165-3806
Ausgabe der Veröffentlichung
2
Zeitschrift
Developmental Brain Research
Sprache
en
Paginierung
219 - 223
Datum der Veröffentlichung
1999
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/s0165-3806(99)00123-6
Datum der Datenerfassung
2023
Titel
Thy-1 is critical for normal retinal development
Ausgabe der Zeitschrift
117

Datenquelle: Crossref

Abstract
In the mammalian retina, Thy-1, the most abundant mammalian neuronal surface glycoprotein, is found predominantly if not exclusively on retinal ganglion cells. We hypothesized that Thy-1 plays a significant role in retinal development. Neurite outgrowth of retinal ganglion cells from Thy-1(-) mice over multiple substrates was compared to that seen with wild-type controls. Adult mouse retinas were histologically compared between Thy-1(-) and three strains of Thy-1 positive mice. Thy-1(-) retinal ganglion cells had significantly less neurite outgrowth than controls. The inner nuclear, inner plexiform, ganglion cell and outer segment/pigment epithelium layers were thinner in Thy-1(-) retinae than in controls. Thy-1 appears to be critical for normal retinal development.
Addresses
  • The Department of Ophthalmology, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA, USA.
Autoren
  • PD Simon
  • J McConnell
  • D Zurakowski
  • CK Vorwerk
  • R Naskar
  • CL Grosskreutz
  • EB Dreyer
DOI
10.1016/s0165-3806(99)00123-6
Externe Identifier
  • PubMed Identifier: 10567740
Funding acknowledgements
  • NEI NIH HHS: R01 EY10009
Open access
false
ISSN
0165-3806
Ausgabe der Veröffentlichung
2
Zeitschrift
Brain research. Developmental brain research
Schlüsselwörter
  • Neurites
  • Retinal Ganglion Cells
  • Retina
  • Animals
  • Mice, Inbred Strains
  • Mice, Knockout
  • Mice
  • In Vitro Techniques
  • Thy-1 Antigens
Sprache
eng
Medium
Print
Paginierung
219 - 223
Datum der Veröffentlichung
1999
Status
Published
Publisher licence
CC BY-NC-ND
Datum der Datenerfassung
1999
Titel
Thy-1 is critical for normal retinal development.
Sub types
  • Research Support, U.S. Gov't, P.H.S.
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
117

Datenquelle: Europe PubMed Central

Abstract
In the mammalian retina, Thy-1, the most abundant mammalian neuronal surface glycoprotein, is found predominantly if not exclusively on retinal ganglion cells. We hypothesized that Thy-1 plays a significant role in retinal development. Neurite outgrowth of retinal ganglion cells from Thy-1(-) mice over multiple substrates was compared to that seen with wild-type controls. Adult mouse retinas were histologically compared between Thy-1(-) and three strains of Thy-1 positive mice. Thy-1(-) retinal ganglion cells had significantly less neurite outgrowth than controls. The inner nuclear, inner plexiform, ganglion cell and outer segment/pigment epithelium layers were thinner in Thy-1(-) retinae than in controls. Thy-1 appears to be critical for normal retinal development.
Autoren
  • PD Simon
  • J McConnell
  • D Zurakowski
  • CK Vorwerk
  • R Naskar
  • CL Grosskreutz
  • EB Dreyer
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/10567740
DOI
10.1016/s0165-3806(99)00123-6
Funding acknowledgements
  • NEI NIH HHS: R01 EY10009
ISSN
0165-3806
Ausgabe der Veröffentlichung
2
Zeitschrift
Brain Res Dev Brain Res
Schlüsselwörter
  • Animals
  • In Vitro Techniques
  • Mice
  • Mice, Inbred Strains
  • Mice, Knockout
  • Neurites
  • Retina
  • Retinal Ganglion Cells
  • Thy-1 Antigens
Sprache
eng
Country
Netherlands
Paginierung
219 - 223
PII
S0165380699001236
Datum der Veröffentlichung
1999
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2000
Titel
Thy-1 is critical for normal retinal development.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
Ausgabe der Zeitschrift
117

Datenquelle: PubMed

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