The Functional Muscle-Bone Unit in Obese Children - Altered Bone Structure Leads to Normal Strength Strain Index

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • S Ehehalt
  • G Binder
  • N Schurr
  • C Pfaff
  • MB Ranke
  • R Schweizer
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000293115500001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1055/s-0031-1277139
eISSN
1439-3646
Externe Identifier
  • Clarivate Analytics Document Solution ID: 797HQ
  • PubMed Identifier: 21553367
ISSN
0947-7349
Ausgabe der Veröffentlichung
6
Zeitschrift
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Schlüsselwörter
  • obesity
  • children
  • functional muscle-bone unit
  • DXA
  • PQCT
Paginierung
321 - 326
Datum der Veröffentlichung
2011
Status
Published
Titel
The Functional Muscle-Bone Unit in Obese Children - Altered Bone Structure Leads to Normal Strength Strain Index
Sub types
  • Article
Ausgabe der Zeitschrift
119

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • S Ehehalt
  • G Binder
  • N Schurr
  • C Pfaff
  • MB Ranke
  • R Schweizer
DOI
10.1055/s-0031-1277139
eISSN
1439-3646
ISSN
0947-7349
Ausgabe der Veröffentlichung
06
Zeitschrift
Experimental and Clinical Endocrinology & Diabetes
Sprache
en
Online publication date
2011
Paginierung
321 - 326
Status
Published online
Herausgeber
Georg Thieme Verlag KG
Herausgeber URL
http://dx.doi.org/10.1055/s-0031-1277139
Datum der Datenerfassung
2023
Titel
The Functional Muscle-Bone Unit in Obese Children – Altered Bone Structure Leads to Normal Strength Strain Index
Ausgabe der Zeitschrift
119

Datenquelle: Crossref

Abstract
<h4>Unlabelled</h4>Obese children have a twofold increased risk of fracture of the forearm compared to non-obese children.<h4>Objective</h4>To investigate bone strength and bone structure of the forearm, and the relationship between muscle and bone in obese children.<h4>Methods</h4>The study-group consisted of 84 (40 female) overweight children (mean (SD)) age 11.8 (3.2) years, BMI 29.0 (5.1) kg/m(2)). Bone geometry and strength were measured at the proximal radius of the non-dominant forearm (65% measurement site) by means of pQCT (XCT 2000). Bone mineral density and lean mass of the total body was determined by means of DXA (Lunar, DPXL/PED). Results were compared to reference values by calculating age (SDS(CA)) and height-age (SDS(HA)) dependent standard deviation scores (SDS).<h4>Results</h4>Cortical density, -1.11 (1.74) SDS(HA), -0.45 (1.52) SDS(CA); cortical thickness, -1.46 (1.33) SDS(HA), -1.01 (1.46) SDS(CA); cortical area, -0.42 (1.31) SDS(HA), 0.26 (1.58) SDS(CA); total bone area +2.21 (1.47) SDS(HA), 2.91 (1.80) SDS(CA), marrow area +3.12 (2.29) SDS(HA), 3.37 (2.38) SDS(CA); strength strain index +0.10 (1.10) SDS(HA), 0.95 (1.57) SDS(CA). These changes in bone structure were independent from pubertal stage. Measurements revealed correlations between muscle area and SSI (R(2)=0.67, p<0.001), and muscle mass and bone mineral content (DXA; R (2)=0.81, p<0.001).<h4>Conclusion</h4>Low cortical density, normal cortical area and increased total bone area led to a normal strength strain index adjusted both for height and for age. We assume that this normal bone strength is not appropriate for the higher kinetic energy of impact in case of a fall in overweight children.
Addresses
  • Pediatric Endocrinology and Diabetology, University Children's Hospital, Tuebingen, Germany.
Autoren
  • S Ehehalt
  • G Binder
  • N Schurr
  • C Pfaff
  • MB Ranke
  • R Schweizer
  • DISKUS-Study Group
DOI
10.1055/s-0031-1277139
eISSN
1439-3646
Externe Identifier
  • PubMed Identifier: 21553367
Open access
false
ISSN
0947-7349
Ausgabe der Veröffentlichung
6
Zeitschrift
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Schlüsselwörter
  • DISKUS-Study Group
  • Musculoskeletal System
  • Muscle, Skeletal
  • Bone and Bones
  • Humans
  • Bone Diseases, Developmental
  • Obesity
  • Sprains and Strains
  • Health Status Indicators
  • Cohort Studies
  • Age of Onset
  • Models, Biological
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Male
  • Muscle Strength
  • Young Adult
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
321 - 326
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
The functional muscle-bone unit in obese children - altered bone structure leads to normal strength strain index.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
119

Datenquelle: Europe PubMed Central

Abstract
UNLABELLED: Obese children have a twofold increased risk of fracture of the forearm compared to non-obese children. OBJECTIVE: To investigate bone strength and bone structure of the forearm, and the relationship between muscle and bone in obese children. METHODS: The study-group consisted of 84 (40 female) overweight children (mean (SD)) age 11.8 (3.2) years, BMI 29.0 (5.1) kg/m(2)). Bone geometry and strength were measured at the proximal radius of the non-dominant forearm (65% measurement site) by means of pQCT (XCT 2000). Bone mineral density and lean mass of the total body was determined by means of DXA (Lunar, DPXL/PED). Results were compared to reference values by calculating age (SDS(CA)) and height-age (SDS(HA)) dependent standard deviation scores (SDS). RESULTS: Cortical density, -1.11 (1.74) SDS(HA), -0.45 (1.52) SDS(CA); cortical thickness, -1.46 (1.33) SDS(HA), -1.01 (1.46) SDS(CA); cortical area, -0.42 (1.31) SDS(HA), 0.26 (1.58) SDS(CA); total bone area +2.21 (1.47) SDS(HA), 2.91 (1.80) SDS(CA), marrow area +3.12 (2.29) SDS(HA), 3.37 (2.38) SDS(CA); strength strain index +0.10 (1.10) SDS(HA), 0.95 (1.57) SDS(CA). These changes in bone structure were independent from pubertal stage. Measurements revealed correlations between muscle area and SSI (R(2)=0.67, p<0.001), and muscle mass and bone mineral content (DXA; R (2)=0.81, p<0.001). CONCLUSION: Low cortical density, normal cortical area and increased total bone area led to a normal strength strain index adjusted both for height and for age. We assume that this normal bone strength is not appropriate for the higher kinetic energy of impact in case of a fall in overweight children.
Autoren
  • S Ehehalt
  • G Binder
  • N Schurr
  • C Pfaff
  • MB Ranke
  • R Schweizer
  • DISKUS-Study Group
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21553367
DOI
10.1055/s-0031-1277139
eISSN
1439-3646
Ausgabe der Veröffentlichung
6
Zeitschrift
Exp Clin Endocrinol Diabetes
Schlüsselwörter
  • Adolescent
  • Adult
  • Age of Onset
  • Bone Diseases, Developmental
  • Bone and Bones
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Health Status Indicators
  • Humans
  • Male
  • Models, Biological
  • Muscle Strength
  • Muscle, Skeletal
  • Musculoskeletal System
  • Obesity
  • Sprains and Strains
  • Young Adult
Sprache
eng
Country
Germany
Paginierung
321 - 326
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
The functional muscle-bone unit in obese children - altered bone structure leads to normal strength strain index.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
119

Datenquelle: PubMed

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