Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Lukas Hahn
- Matthias Maier
- Philipp Stahlhut
- Matthias Beudert
- Vanessa Flegler
- Stefan Forster
- Alexander Altmann
- Fabian Toeppke
- Karl Fischer
- Sebastian Seiffert
- Bettina Boettcher
- Tessa Luehmann
- Robert Luxenhofer
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000526543400007&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1021/acsami.9b21282
- eISSN
- 1944-8252
- Externe Identifier
- Clarivate Analytics Document Solution ID: LE2HF
- PubMed Identifier: 32142257
- ISSN
- 1944-8244
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- ACS APPLIED MATERIALS & INTERFACES
- Schlüsselwörter
- poly(2-oxazoline)
- dispense plotting
- biomaterial ink
- smart hydrogel
- wormlike micelles
- Paginierung
- 12445 - 12456
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks
- Sub types
- Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Lukas Hahn
- Matthias Maier
- Philipp Stahlhut
- Matthias Beudert
- Vanessa Flegler
- Stefan Forster
- Alexander Altmann
- Fabian Töppke
- Karl Fischer
- Sebastian Seiffert
- Bettina Böttcher
- Tessa Lühmann
- Robert Luxenhofer
- DOI
- 10.1021/acsami.9b21282
- eISSN
- 1944-8252
- ISSN
- 1944-8244
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- ACS Applied Materials & Interfaces
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 12445 - 12456
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/acsami.9b21282
- Datum der Datenerfassung
- 2023
- Titel
- Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks
- Ausgabe der Zeitschrift
- 12
Datenquelle: Crossref
- Abstract
- Amphiphilic block copolymers that undergo (reversible) physical gelation in aqueous media are of great interest in different areas including drug delivery, tissue engineering, regenerative medicine, and biofabrication. We investigated a small library of ABA-type triblock copolymers comprising poly(2-methyl-2-oxazoline) as the hydrophilic shell A and different aromatic poly(2-oxazoline)s and poly(2-oxazine)s cores B in an aqueous solution at different concentrations and temperatures. Interestingly, aqueous solutions of poly(2-methyl-2-oxazoline)-<i>block</i>-poly(2-phenyl-2-oxazine)-<i>block</i>-poly(2-methyl-2-oxazoline) (PMeOx-<i>b</i>-PPheOzi-<i>b</i>-PMeOx) undergo inverse thermogelation below a critical temperature by forming a reversible nanoscale wormlike network. The viscoelastic properties of the resulting gel can be conveniently tailored by the concentration and the polymer composition. Storage moduli of up to 110 kPa could be obtained while the material retains shear-thinning and rapid self-healing properties. We demonstrate three-dimensional (3D) printing of excellently defined and shape-persistent 24-layered scaffolds at different aqueous concentrations to highlight its application potential, e.g., in the research area of biofabrication. A macroporous microstructure, which is stable throughout the printing process, could be confirmed via cryo-scanning electron microscopy (SEM) analysis. The absence of cytotoxicity even at very high concentrations opens a wide range of different applications for this first-in-class material in the field of biomaterials.
- Addresses
- Functional Polymer Materials, Chair for Advanced Materials Synthesis, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, Julius-Maximilians-University Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
- Autoren
- Lukas Hahn
- Matthias Maier
- Philipp Stahlhut
- Matthias Beudert
- Vanessa Flegler
- Stefan Forster
- Alexander Altmann
- Fabian Töppke
- Karl Fischer
- Sebastian Seiffert
- Bettina Böttcher
- Tessa Lühmann
- Robert Luxenhofer
- DOI
- 10.1021/acsami.9b21282
- eISSN
- 1944-8252
- Externe Identifier
- PubMed Identifier: 32142257
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: 398461692
- Deutsche Forschungsgemeinschaft: 326998133 ? TRR 225
- Open access
- false
- ISSN
- 1944-8244
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- ACS applied materials & interfaces
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Paginierung
- 12445 - 12456
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum der Datenerfassung
- 2020
- Titel
- Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: Europe PubMed Central
- Abstract
- Amphiphilic block copolymers that undergo (reversible) physical gelation in aqueous media are of great interest in different areas including drug delivery, tissue engineering, regenerative medicine, and biofabrication. We investigated a small library of ABA-type triblock copolymers comprising poly(2-methyl-2-oxazoline) as the hydrophilic shell A and different aromatic poly(2-oxazoline)s and poly(2-oxazine)s cores B in an aqueous solution at different concentrations and temperatures. Interestingly, aqueous solutions of poly(2-methyl-2-oxazoline)-block-poly(2-phenyl-2-oxazine)-block-poly(2-methyl-2-oxazoline) (PMeOx-b-PPheOzi-b-PMeOx) undergo inverse thermogelation below a critical temperature by forming a reversible nanoscale wormlike network. The viscoelastic properties of the resulting gel can be conveniently tailored by the concentration and the polymer composition. Storage moduli of up to 110 kPa could be obtained while the material retains shear-thinning and rapid self-healing properties. We demonstrate three-dimensional (3D) printing of excellently defined and shape-persistent 24-layered scaffolds at different aqueous concentrations to highlight its application potential, e.g., in the research area of biofabrication. A macroporous microstructure, which is stable throughout the printing process, could be confirmed via cryo-scanning electron microscopy (SEM) analysis. The absence of cytotoxicity even at very high concentrations opens a wide range of different applications for this first-in-class material in the field of biomaterials.
- Autoren
- Lukas Hahn
- Matthias Maier
- Philipp Stahlhut
- Matthias Beudert
- Vanessa Flegler
- Stefan Forster
- Alexander Altmann
- Fabian Töppke
- Karl Fischer
- Sebastian Seiffert
- Bettina Böttcher
- Tessa Lühmann
- Robert Luxenhofer
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/32142257
- DOI
- 10.1021/acsami.9b21282
- eISSN
- 1944-8252
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- ACS Appl Mater Interfaces
- Schlüsselwörter
- biomaterial ink
- dispense plotting
- poly(2-oxazoline)
- smart hydrogel
- wormlike micelles
- Sprache
- eng
- Country
- United States
- Paginierung
- 12445 - 12456
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Titel
- Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: PubMed
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