The latent structure of the functional dyspepsia symptom complex: a taxometric analysis

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • L Van Oudenhove
  • F Jasper
  • M Walentynowicz
  • M Witthoft
  • O Van den Bergh
  • J Tack
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000383290800004&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1111/nmo.12798
eISSN
1365-2982
Externe Identifier
  • Clarivate Analytics Document Solution ID: DV9VR
  • PubMed Identifier: 27339217
ISSN
1350-1925
Ausgabe der Veröffentlichung
7
Zeitschrift
NEUROGASTROENTEROLOGY AND MOTILITY
Schlüsselwörter
  • epigastric pain syndrome
  • factor analysis
  • functional dyspepsia
  • functional gastrointestinal disorders
  • postprandial distress syndrome
  • taxometric analysis
Paginierung
985 - 993
Datum der Veröffentlichung
2016
Status
Published
Titel
The latent structure of the functional dyspepsia symptom complex: a taxometric analysis
Sub types
  • Article
Ausgabe der Zeitschrift
28

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>Rome <jats:styled-content style="fixed-case">III</jats:styled-content> introduced a subdivision of functional dyspepsia (<jats:styled-content style="fixed-case">FD</jats:styled-content>) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of <jats:styled-content style="fixed-case">FD</jats:styled-content> to test whether distinguishable symptom‐based subgroups exist.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Consecutive tertiary care Rome <jats:styled-content style="fixed-case">II FD</jats:styled-content> patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (<jats:styled-content style="fixed-case">CFA</jats:styled-content>) was used to compare the fit of a single factor model, a correlated three‐factor model based on Rome <jats:styled-content style="fixed-case">III</jats:styled-content> subgroups and a bifactor model consisting of a general <jats:styled-content style="fixed-case">FD</jats:styled-content> factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of <jats:styled-content style="fixed-case">FD</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Key Results</jats:title><jats:p>Nine hundred and fifty‐seven <jats:styled-content style="fixed-case">FD</jats:styled-content> patients (71.1% women, age 41 ± 14.8) participated. In <jats:styled-content style="fixed-case">CFA</jats:styled-content>, the bifactor model yielded a significantly better fit than the two other models (<jats:italic>χ</jats:italic>² difference tests both <jats:italic>p</jats:italic> &lt; 0.001). All symptoms had significant loadings on both the general and the subgroup‐specific factors (all <jats:italic>p</jats:italic> &lt; 0.05). Somatization was associated with the general (<jats:italic>r </jats:italic>= 0.72, <jats:italic>p</jats:italic> &lt; 0.01), but not the subgroup‐specific factors (all <jats:italic>r</jats:italic> &lt; 0.13, <jats:italic>p</jats:italic> &gt; 0.05). Taxometric analyses supported a dimensional structure of <jats:styled-content style="fixed-case">FD</jats:styled-content> (all <jats:styled-content style="fixed-case">CCFI</jats:styled-content>&lt;0.38).</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Inferences</jats:title><jats:p>We found a dimensional rather than categorical latent structure of the <jats:styled-content style="fixed-case">FD</jats:styled-content> symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom‐specific factors reflecting the Rome <jats:styled-content style="fixed-case">III</jats:styled-content> subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of <jats:styled-content style="fixed-case">FD</jats:styled-content>.</jats:p></jats:sec>
Autoren
  • L Van Oudenhove
  • F Jasper
  • M Walentynowicz
  • M Witthöft
  • O Van den Bergh
  • J Tack
DOI
10.1111/nmo.12798
eISSN
1365-2982
ISSN
1350-1925
Ausgabe der Veröffentlichung
7
Zeitschrift
Neurogastroenterology &amp; Motility
Sprache
en
Online publication date
2016
Paginierung
985 - 993
Datum der Veröffentlichung
2016
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/nmo.12798
Datum der Datenerfassung
2023
Titel
The latent structure of the functional dyspepsia symptom complex: a taxometric analysis
Ausgabe der Zeitschrift
28

Datenquelle: Crossref

Abstract
<h4>Objectives</h4>Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of FD to test whether distinguishable symptom-based subgroups exist.<h4>Methods</h4>Consecutive tertiary care Rome II FD patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (CFA) was used to compare the fit of a single factor model, a correlated three-factor model based on Rome III subgroups and a bifactor model consisting of a general FD factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of FD.<h4>Key results</h4>Nine hundred and fifty-seven FD patients (71.1% women, age 41 ± 14.8) participated. In CFA, the bifactor model yielded a significantly better fit than the two other models (χ² difference tests both p < 0.001). All symptoms had significant loadings on both the general and the subgroup-specific factors (all p < 0.05). Somatization was associated with the general (r = 0.72, p < 0.01), but not the subgroup-specific factors (all r < 0.13, p > 0.05). Taxometric analyses supported a dimensional structure of FD (all CCFI<0.38).<h4>Conclusions and inferences</h4>We found a dimensional rather than categorical latent structure of the FD symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom-specific factors reflecting the Rome III subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of FD.
Addresses
  • Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium.
Autoren
  • L Van Oudenhove
  • F Jasper
  • M Walentynowicz
  • M Witthöft
  • O Van den Bergh
  • J Tack
DOI
10.1111/nmo.12798
eISSN
1365-2982
Externe Identifier
  • PubMed Identifier: 27339217
Funding acknowledgements
  • Methusalem grant from Leuven University:
Open access
false
ISSN
1350-1925
Ausgabe der Veröffentlichung
7
Zeitschrift
Neurogastroenterology and motility
Schlüsselwörter
  • Humans
  • Abdominal Pain
  • Dyspepsia
  • Nausea
  • Postprandial Period
  • Classification
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Middle Aged
  • Female
  • Male
  • Young Adult
  • Tertiary Healthcare
  • Surveys and Questionnaires
Sprache
eng
Medium
Print
Paginierung
985 - 993
Datum der Veröffentlichung
2016
Status
Published
Datum der Datenerfassung
2016
Titel
The latent structure of the functional dyspepsia symptom complex: a taxometric analysis.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
28

Datenquelle: Europe PubMed Central

Abstract
OBJECTIVES: Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of FD to test whether distinguishable symptom-based subgroups exist. METHODS: Consecutive tertiary care Rome II FD patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (CFA) was used to compare the fit of a single factor model, a correlated three-factor model based on Rome III subgroups and a bifactor model consisting of a general FD factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of FD. KEY RESULTS: Nine hundred and fifty-seven FD patients (71.1% women, age 41 ± 14.8) participated. In CFA, the bifactor model yielded a significantly better fit than the two other models (χ² difference tests both p < 0.001). All symptoms had significant loadings on both the general and the subgroup-specific factors (all p < 0.05). Somatization was associated with the general (r = 0.72, p < 0.01), but not the subgroup-specific factors (all r < 0.13, p > 0.05). Taxometric analyses supported a dimensional structure of FD (all CCFI<0.38). CONCLUSIONS AND INFERENCES: We found a dimensional rather than categorical latent structure of the FD symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom-specific factors reflecting the Rome III subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of FD.
Date of acceptance
2016
Autoren
  • L Van Oudenhove
  • F Jasper
  • M Walentynowicz
  • M Witthöft
  • O Van den Bergh
  • J Tack
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/27339217
DOI
10.1111/nmo.12798
eISSN
1365-2982
Ausgabe der Veröffentlichung
7
Zeitschrift
Neurogastroenterol Motil
Schlüsselwörter
  • epigastric pain syndrome
  • factor analysis
  • functional dyspepsia
  • functional gastrointestinal disorders
  • postprandial distress syndrome
  • taxometric analysis
  • Abdominal Pain
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Classification
  • Dyspepsia
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nausea
  • Postprandial Period
  • Surveys and Questionnaires
  • Tertiary Healthcare
  • Young Adult
Sprache
eng
Country
England
Paginierung
985 - 993
Datum der Veröffentlichung
2016
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
The latent structure of the functional dyspepsia symptom complex: a taxometric analysis.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
28

Datenquelle: PubMed

Autoren
  • L Van Oudenhove
  • F Jasper
  • M Walentynowicz
  • M Witthöft
  • O Van den Bergh
  • J Tack
DOI
10.1111/nmo.12798
ISSN
1350-1925
Ausgabe der Veröffentlichung
7
Zeitschrift
Neurogastroenterology & Motility
Sprache
en
Online publication date
2016
Paginierung
985 - 993
Datum der Veröffentlichung
2016
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/nmo.12798
Datum der Datenerfassung
2022
Titel
The latent structure of the functional dyspepsia symptom complex: a taxometric analysis
Ausgabe der Zeitschrift
28

Datenquelle: Manual

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